TGF-alpha Proteins, Antibodies, cDNA Clones Research Reagents

TGFA (Transforming Growth Factor Alpha) is a protein coding gene located on human chromosome 2p13.3. TGFA is also known as TFGA. The human TGFA gene encodes a 17006 Da protein containing 160 amino acids. The TGFA protein is broadly expressed in esophagus, gall bladder and other tissues. Among its related pathways are Association Between Physico-Chemical Features and Toxicity Associated Pathways and NF-KappaB Family Pathway. TGFA is related to growth factor activity and epidermal growth factor receptor binding. BTC is an important paralog of TGFA gene. TGFA is associated with some diseases, including Tooth Agenesis and Cholesteatoma Of Middle Ear.

TGF-alpha Protein (1)

    TGF-alpha Antibody (3)

      TGF-alpha cDNA Clone (26)

      NM_003236.2
      NM_031199.2

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      TGF-alpha Background

      The miR-137 served as a tumor suppressor in non-small cell lung cancer (NSCLC) and its suppressive effect is mediated by repressing TGFA expression. TGFA gene expression was significantly higher in tumor tissues compared to adjacent normal tissue and high TGFA gene expression strongly correlated with poor survival in patients with lung adenocarcinoma, and miR-374a suppresses lung adenocarcinoma cell proliferation and invasion via targeting TGFA gene expression. Transforming growth factor alpha (TGFA) is a well-characterized mammalian growth factor that might contribute to the development of Cleft lip and palate (CL/P).

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