TAB1 Antibodies, cDNA Clones Research Reagents

TAB1 (TGF-Beta Activated Kinase 1 (MAP3K7) Binding Protein 1, also known as 3'-Tab1; MAP3K7IP1), located on 22q13.1, is a Protein Coding gene. The gene produces a 54644 Da protein composed of 504 amino acids. TAK1, a mitogen-activated kinase kinase kinase, is involved in several distinct signaling pathways including non-Smad pathways for TGF-beta superfamily members and inflammatory responses caused by cytokines. The Diseases such as Ectodermal Dysplasia 10A, Hypohidrotic/Hair/Nail Type, Autosomal Dominant, and Frontometaphyseal Dysplasia are associated with TAB1.

TAB1 Antibody (1)

    TAB1 cDNA Clone (16)

    NM_025609.2

    In expression vector

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    TAB1 Background

    TGF-β activated kinase-1 binding protein-1 (TAB1) binds and induces autophosphorylation of TGF-beta activating kinase (TAK1). TAB1 is an upstream adaptor for the activation of the kinase TAK1, which in turn couples to the NF-kappaB pathway. TAB1 forms the protein complex with TAK1 and enhances its kinase activity in the human and mammals. TAK1, a mitogen-activated kinase kinase kinase, is involved in several distinct signaling pathways including non-Smad pathways for TGF-beta superfamily members and inflammatory responses caused by cytokines. Conventional disruption of the murine Tab1 gene results in late gestational lethality showing intraventricular septum defects and underdeveloped lung alveoli. A single O-GlcNAc site has been identified on human TAB1 that modulates TAK1-mediated cytokine release in cells.

    TAB1 References

    • Zou Z, et al. (2019) Black carp tab1 up-regulates tak1/irf7/ifn signaling during the antiviral innate immune activation. Fish Shellfish Immunol 89 736-744.
    • Inagaki M, et al. (2008) Generation of a conditional mutant allele for tab1 in mouse. Genesis 46 (8): 431-439.
    • Authier F, et al. (2019) A mouse model for functional dissection of tab1 o-glcnacylation. Wellcome Open Res 4 128.

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