Syndecan-1/CD138 Proteins, Antibodies, cDNA Clones Research Reagents

SDC1 (Syndecan 1) is a protein coding gene located on human chromosome 2p24.1. SDC1 is also known as SDC, CD138, SYND1 and syndecan. The human SDC1 gene encodes a 32462 Da protein containing 310 amino acids. The SDC1 protein is broadly expressed in esophagus, skin and other tissues. Among its related pathways are Signaling by GPCR and Development HGF signaling pathway. SDC1 is related to protein C-terminus binding. SDC3 is an important paralog of SDC1 gene. SDC1 is associated with some diseases, including Monoclonal Gammopathy Of Uncertain Significance and Granulomatous Endometritis.

Syndecan-1/CD138 Protein (5)

    Syndecan-1/CD138 Antibody (18)

      Syndecan-1/CD138 cDNA Clone (41)


      In expression vector

      Syndecan-1/CD138 Lysate (5)

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        Syndecan-1/CD138 Background

        Syndecan-1 also known as SDC1 and CD138, is the most extensively studied member of the syndecan family. It is found mainly in epithelial cells, but its expression is developmentally regulated during embryonic development. Syndecan-1/SDC1/CD138 has been shown to mediate cell adhesion to several ECM molecules, and to act as a coreceptor for fibroblast growth factors, potent angiogenic growth factors involved also in differentiation. Syndecan-1/SDC1/CD138 expression is reduced during malignant transformation of various epithelia, and this loss correlates with the histological differentiation grade of squamous cell carcinomas, lacking from poorly differentiated tumours. In squamous cell carcinomas of the head and neck, positive syndecan-1 expression correlates with a more favourable prognosis. Experimental studies on the role of Syndecan-1 in malignant transformation have shown that Syndecan-1/SDC1/CD138 expression is associated with the maintenance of epithelial morphology, anchorage-dependent growth and inhibition of invasiveness in vitro.

        Syndecan-1/CD138 References

        • Inki P, et al. (1996) The role of syndecan-1 in malignancies. Ann Med. 28(1): 63-7.
        • Subramanian SV, et al. (1997) Regulated shedding of syndecan-1 and -4 ectodomains by thrombin and growth factor receptor activation. J Biol Chem. 272(23): 14713-20.
        • Park PW, et al. (2001) Exploitation of syndecan-1 shedding by Pseudomonas aeruginosa enhances virulence. Nature. 411(6833): 98-102.

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