Syk cDNA Clones Research Reagents

SYK (Spleen Associated Tyrosine Kinase) is a protein coding gene located on human chromosome 9q22.2. SYK is also known as p72-Syk. The human SYK gene encodes a 72066 Da protein containing 635 amino acids. The SYK protein is broadly expressed in lymph node, appendix and other tissues. Among its related pathways are B cell receptor signaling pathway (KEGG) and Signaling by GPCR. SYK is related to transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. ZAP70 is an important paralog of SYK gene. SYK is associated with some diseases, including Peripheral T-Cell Lymphoma and Hantavirus Pulmonary Syndrome.

Syk cDNA Clone (13)

NM_003177.5

Syk qPCR Primer (1)

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Syk Background

SYK gene encodes a member of the family of non-receptor type Tyr protein kinases. This protein is widely expressed in hematopoietic cells and is involved in coupling activated immunoreceptors to downstream signaling events that mediate diverse cellular responses, including proliferation, differentiation, and phagocytosis. It is thought to be a modulator of epithelial cell growth and a potential tumour suppressor in human breast carcinomas. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Syk References

  • Boros K, Puissant A, Back M, et al. Increased SYK activity is associated with unfavorable outcome among patients with acute myeloid leukemia. Oncotarget. 2015;6(28):25575-25587.

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