SUMO1 Proteins, Antibodies, cDNA Clones Research Reagents

SUMO1 (Small Ubiquitin Like Modifier 1) is a protein coding gene located on human chromosome 2q33.1. SUMO1 is also known as DAP1, GMP1, PIC1, SMT3, UBL1, OFC10, SENP2, SMT3C and SMT3H3. The human SUMO1 gene encodes a 11557 Da protein containing 101 amino acids. The SUMO1 protein is ubiquitously expressed in thyroid, adrenal and other tissues. Among its related pathways are HIF Repressors and Androgen receptor signaling pathway. SUMO1 is related to ubiquitin protein ligase binding. SUMO1 is associated with some diseases, including Orofacial Cleft 10 and Cleft Lip.

SUMO1 Protein (1)

    SUMO1 Antibody (3)

      SUMO1 cDNA Clone (60)

      SUMO1 qPCR Primer (2)

      SUMO1 Background

      Small ubiquitin-like modifier protein (SUMO) modification is a highly dynamic process, catalyzed by SUMO-specific activating (E1), conjugating (E2) and ligating (E3) enzymes, and reversed by a family of SUMO-specific proteases (SENPs). Small ubiquitin-like modifier 1 (SUMO1) is a member of the superfamily of ubiquitin-like proteins. Despite its structural similarity with ubiquitin, SUMO1 does not seem to play any role in protein degradation. SUMO1 plays an important role in modulation of NOX activity required for ROS generation. SUMO1 haploinsufficiency results in cleft lip and palate in animal models. SUMO1 gene variation in human non-syndromic cleft lip with or without cleft palate (NSCLP) development. SUMO-1 may be useful as a novel target for therapy in oral squamous cell carcinoma (SCC) as well as a clinical indicator for tumor recurrence together with Mdm2.

      SUMO1 References

      • Kim HJ, et al. (2011) SUMO1 attenuates stress-induced ROS generation by inhibiting NADPH oxidase 2. Biochem Biophys Res Commun. 410(3): 555-62.
      • Zuo Y, et al. (2009) Small ubiquitin-like modifier protein-specific protease 1 and prostate cancer. Asian J Androl. 11(1): 36-8.
      • Song T, et al. (2008) SUMO1 polymorphisms are associated with non-syndromic cleft lip with or without cleft palate. Biochem Biophys Res Commun. 377(4): 1265-8.
      • Katayama A, et al. (2007) Overexpression of small ubiquitin-related modifier-1 and sumoylated Mdm2 in oral squamous cell carcinoma: possible involvement in tumor proliferation and prognosis. Int J Oncol. 31(3): 517-24.

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