SULT2B1 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

SULT2B1 (Sulfotransferase Family 2B Member 1) is a protein coding gene located on human chromosome 19q13.33. SULT2B1 is also known as HSST2 and ARCI14. The human SULT2B1 gene encodes a 41308 Da protein containing 365 amino acids. The SULT2B1 protein is biasedly expressed in esophagus, skin and other tissues. Among its related pathways are Cytochrome P450 - arranged by substrate type and Sulfation Biotransformation Reaction. SULT2B1 is related to sulfotransferase activity and alcohol sulfotransferase activity. SULT2A1 is an important paralog of SULT2B1 gene. SULT2B1 is associated with some diseases, including Ichthyosis, Congenital, Autosomal Recessive 14 and Ichthyosis, Congenital, Autosomal Recessive 1.

SULT2B1 Protein (1)

    SULT2B1 Antibody (7)

      SULT2B1 ELISA Kit & Match Antibody ELISA Pair Set (1)

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      SULT2B1 Background

      Sulfotransferase family cytosolic 2B member 1, also known as Sulfotransferase 2B1, ST2B1, Alcohol sulfotransferase, Hydroxysteroid sulfotransferase 2, SULT2B1 and HSST2, is a cytoplasm protein that belongs to the sulfotransferase 1 family. The human hydroxysteroid sulfotransferase (SULT) family is comprised of two subfamilies, SULT2A1 and SULT2B1. SULT2B1 is expressed highly in placenta, prostate and trachea. A lesser expression of SULT1B1 was observed in the small intestine and lung. SULT2B1 catalyzes the sulfate conjugation of many hormones, neurotransmitters, drugs and xenobiotic compounds. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. SULT2B1 sulfates hydroxysteroids like DHEA. Isoform 1 preferentially sulfonates cholesterol. The two SULT2B1 isoforms, SULT2B1a and SULT2B1b, are encoded by a single gene as a result of alternative transcription initiation and alternative splicing. SULT2B1b catalyzes the sulfonation of 3beta-hydroxysteroid hormones and cholesterol, whereas SULT2B1a preferentially catalyzes pregnenolone sulfonation.

      SULT2B1 References

      • Fujita K. et al., 1997, J. Biochem. 122:1052-61.
      • Geese,WJ. et al., 2001,Biochem Biophys Res Commun.288 (1): 280-9.
      • Shimizu,C. et al., 2003, Endocrinology. 144 (4):1186-93.
      • Ji,Y. et al., 2007, J Pharmacol Exp Ther. 322 (2): 529-40.

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