STAT6 Proteins, Antibodies, cDNA Clones Research Reagents

STAT6 (Signal Transducer And Activator Of Transcription 6) is a protein coding gene located on human chromosome 12q13.3. STAT6 is also known as STAT6B, STAT6C, D12S1644 and IL-4-STAT. The human STAT6 gene encodes a 94135 Da protein containing 847 amino acids. The STAT6 protein is ubiquitously expressed in spleen, skin and other tissues. Among its related pathways are Signaling by GPCR and GPCR Pathway. STAT6 is related to DNA-binding transcription factor activity and sequence-specific DNA binding. STAT5B is an important paralog of STAT6 gene. STAT6 is associated with some diseases, including Hemangiopericytoma, Malignant and Nut Allergy.

STAT6 Protein (1)

    STAT6 Antibody (6)

      STAT6 cDNA Clone (45)

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        STAT6 Background

        Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that is activated by interleukin-4 (IL-4)-induced tyrosine phosphorylation and mediates most of the IL-4-induced gene expression. STAT6 plays a central role in exerting interleukin-4 (IL-4) mediated biological responses and is found to induce the expression of BCL2L1/BCL-XL, which is responsible for the anti-apoptotic activity of IL4. Transcriptional activation by STAT6 requires the interaction with coactivators like p300 and the CREB-binding protein (CBP). NF-κB and tyrosine-phosphorylated Stat6 can directly bind each other in vitro and in vivo, which suggests that the direct interaction between Stat6 and NF-κB may provide a basis for synergistic activation of transcription by IL-4 and activators of NF-κB.

        STAT6 References

        • Litterst CM, et al. (2001) Transcriptional activation by STAT6 requires the direct interaction with NCoA-1. J Biol Chem. 276 (49): 45713-21.
        • Stutz AM, et al. (1999) Functional synergism of STAT6 with either NF-kappa B or PU.1 to mediate IL-4-induced activation of IgE germline gene transcription. J Immunol. 163 (8): 4383-91.
        • Yang J, et al. (2002) Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II. EMBO J. 21 (18): 4950-8.

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