STAT6 Proteins, Antibodies, cDNA Clones Research Reagents

All STAT6 reagents are produced in house and quality controlled, including 6 STAT6 Antibody, 45 STAT6 Gene, 1 STAT6 IP Kit, 1 STAT6 Lysate, 1 STAT6 Protein, 2 STAT6 qPCR. All STAT6 reagents are ready to use.

STAT6 Protein (1)

    STAT6 Antibody (6)

      STAT6 cDNA Clone (45)

      STAT6 qPCR Primer (2)

      STAT6 Lysate (1)

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        STAT6 Background

        Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that is activated by interleukin-4 (IL-4)-induced tyrosine phosphorylation and mediates most of the IL-4-induced gene expression. STAT6 plays a central role in exerting interleukin-4 (IL-4) mediated biological responses and is found to induce the expression of BCL2L1/BCL-XL, which is responsible for the anti-apoptotic activity of IL4. Transcriptional activation by STAT6 requires the interaction with coactivators like p3 and the CREB-binding protein (CBP). NF-?B and tyrosine-phosphorylated Stat6 can directly bind each other in vitro and in vivo, which suggest that the direct interaction between Stat6 and NF-?B may provide a basis for synergistic activation of transcription by IL-4 and activators of NF-?B.

        STAT6 References

        • Litterst CM, et al. (2001) Transcriptional activation by STAT6 requires the direct interaction with NCoA-1. J Biol Chem. 276 (49): 45713-21.
        • Stutz AM, et al. (1999) Functional synergism of STAT6 with either NF-kappa B or PU.1 to mediate IL-4-induced activation of IgE germline gene transcription. J Immunol. 163 (8): 4383-91.
        • Yang J, et al. (2002) Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II. EMBO J. 21 (18): 4950-8.

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