STAT5b cDNA Clones Research Reagents

STAT5B (Signal Transducer And Activator Of Transcription 5B) is a protein coding gene located on human chromosome 17q21.2. STAT5B is also known as STAT5 and GHISID2. The human STAT5B gene encodes an 89866 Da protein containing 787 amino acids. The STAT5B protein is ubiquitously expressed in fat, ovary and other tissues. Among its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and Signaling by GPCR. STAT5B is related to DNA-binding transcription factor activity and sequence-specific DNA binding. STAT5A is an important paralog of STAT5B gene. STAT5B is associated with some diseases, including Growth Hormone Insensitivity With Immunodeficiency and Acute Promyelocytic Leukemia.
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STAT5b Background

The transcription factor STAT5b is an antitumor target. STAT5b confers gemcitabine chemoresistance and promotes cell adherence and invasiveness in pancreatic cancer cells. Targeting STAT5b may lead to novel therapeutic strategies for PDAC. Signal transducer and activator of transcription 5b (STAT5b) is a growth hormone (GH)-activated transcription factor and a master regulator of sexually dimorphic gene expression in the liver. Disruption of the GH hypothalamo-pituitary-liver axis controlling STAT5b activation can lead to metabolic dysregulation, steatosis, and liver cancer.

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