STAT4 Proteins, Antibodies, cDNA Clones Research Reagents

STAT4 (Signal Transducer And Activator Of Transcription 4) is a protein coding gene located on human chromosome 2q32.2-q32.3. STAT4 is also known as SLEB11. The human STAT4 gene encodes an 85941 Da protein containing 748 amino acids. The STAT4 protein is broadly expressed in testis, lymph node and other tissues. Among its related pathways are Immune response IL-23 signaling pathway and GPCR Pathway. STAT4 is related to DNA-binding transcription factor activity and sequence-specific DNA binding. STAT1 is an important paralog of STAT4 gene. STAT4 is associated with some diseases, including Systemic Lupus Erythematosus 11 and Systemic Lupus Erythematosus.

STAT4 Protein (1)

    STAT4 Antibody (2)

      STAT4 cDNA Clone (1)

      NM_001243835.1

      In expression vector

      STAT4 Lysate (1)

        STAT4 Background

        High expression of STAT4 in gastric cancer predicted a better clinical outcome. STAT4 might be a useful biomarker to identify patients at high risk of recurrence after gastrectomy. Genetic variants in the transcription factor STAT4 are associated with increased susceptibility to systemic lupus erythematosus (SLE) and a more severe disease phenotype.

        STAT4 References

        • Thierfelder WE, et al. (1996) Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature. 382(6587):171-4.
        • Hye-Soon L, et al. (2007) Association of STAT4 with Rheumatoid Arthritis in the Korean Population. Mol Med. 13(9-10): 455-60.
        • Chitnis T, et al. (2001) Effect of targeted disruption of STAT4 and STAT6 on the induction of experimental autoimmune encephalomyelitis. J Clin Invest. 108(5): 739-47.

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