SRFBP1 Proteins, Antibodies, cDNA Clones Research Reagents

All SRFBP1 reagents are produced in house and quality controlled, including 1 SRFBP1 Antibody, 30 SRFBP1 Gene, 1 SRFBP1 IP Kit, 1 SRFBP1 Lysate, 1 SRFBP1 Protein, 2 SRFBP1 qPCR. All SRFBP1 reagents are ready to use.

SRFBP1 Protein (1)

    SRFBP1 Antibody (1)

      SRFBP1 cDNA Clone (30)

      SRFBP1 Lysate (1)

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        SRFBP1 Background

        SRFBP1 contains 7 WD repeats and belongs to the WD repeat STRAP family. SRFBP1 may play a role in the cellular distribution of the SMN complex. The SMN complex plays an essential role in spliceosomal snRNP assembly in the cytoplasm and is required for pre-mRNA splicing in the nucleus. SRFBP1 negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein. SRFBP1 may be involved in regulating transcriptional activation of cardiac genes during the aging process. It also may play a role in biosynthesis and/or processing of SLC2A4 in adipose cells.

        SRFBP1 References

        • Datta PK, et al. (1999) Identification of STRAP, a novel WD domain protein in transforming growth factor-beta signaling. J Biol Chem. 273(52):34671-4.
        • Datta PK, et al. (1998) Identification of STRAP, a novel WD domain protein in transforming growth factor-beta signaling. J Biol Chem. 273(52):34671-4.
        • Datta PK, et al. (2000) STRAP and Smad7 synergize in the inhibition of transforming growth factor beta signaling. Mol Cell Biol. 20(9):3157-67.

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