SOCS4 Antibodies, cDNA Clones Research Reagents

SOCS4 (Suppressor Of Cytokine Signaling 4) is a protein coding gene located on human chromosome 14q22.3. SOCS4 is also known as SOCS7. The human SOCS4 gene encodes a 50623 Da protein containing 440 amino acids. The SOCS4 protein is ubiquitously expressed in appendix, lymph node and other tissues. Among its related pathways are IL-2 Pathway and PEDF Induced Signaling. SOCS4 is related to protein kinase inhibitor activity. SOCS5 is an important paralog of SOCS4 gene. SOCS4 is associated with some diseases, including Borderline Glaucoma and Endometrial Stromal Sarcoma.

SOCS4 Antibody (1)

    SOCS4 cDNA Clone (15)

    SOCS4 qPCR Primer (1)

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    SOCS4 Background

    Suppressor of cytokine signaling (SOCS) proteins are key regulators of innate and adaptive immunity. Mice lacking functional SOCS4 are hypersusceptible to primary infection with influenza A virus (IAV), displaying dysregulated pro-inflammatory cytokine and chemokine production in the lungs, delayed viral clearance and impaired trafficking of influenza-specific CD8(+) T cells to the site of infection. SOCS4 is a known inhibitor of epidermal growth factor (EGF) receptor signalling, and functional studies demonstrated specific upregulation of EGF-dependent immune stimulation in affected family members.

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