SOCS3 Proteins, cDNA Clones Research Reagents

SOCS3 (Suppressor Of Cytokine Signaling 3) is a protein coding gene located on human chromosome 17q25.3. SOCS3 is also known as CIS3, SSI3, ATOD4, Cish3, SSI-3 and SOCS-3. The human SOCS3 gene encodes a 24770 Da protein containing 225 amino acids. The SOCS3 protein is broadly expressed in gall bladder, urinary bladder and other tissues. Among its related pathways are Interleukin-11 Signaling Pathway and Signaling by GPCR. SOCS3 is related to protein kinase inhibitor activity. CISH is an important paralog of SOCS3 gene. SOCS3 is associated with some diseases, including Dermatitis, Atopic, 4 and Overnutrition.

SOCS3 Protein (1)

    SOCS3 cDNA Clone (27)

    SOCS3 qPCR Primer (1)

    SOCS3 Background

    Suppressor of cytokine signaling 3, also known as SOCS-3, Cytokine-inducible SH2 protein 3, CIS-3, STAT-induced STAT inhibitor 3, SOCS3 and CIS3, is a protein which is widely expressed with high expression in heart, placenta, skeletal muscle, peripheral blood leukocytes, fetal and adult lung, and fetal liver and kidney. SOCS3 / CIS3 contains one SH2 domain and one SOCS box domain. SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS3 / CIS3 is involved in negative regulation of cytokines that signal through the JAK / STAT pathway. SOCS3 / CIS3 inhibits cytokine signal transduction by binding to tyrosine kinase receptors including gp13, LIF, erythropoietin, insulin, IL12, GCSF and leptin receptors. Binding to JAK2 inhibits its kinase activity. SOCS3 / CIS3 suppresses fetal liver erythropoiesis. It regulates onset and maintenance of allergic responses mediated by T-helper type 2 cells. SOCS3 / CIS3 regulates IL-6 signaling. SOCS3 / CIS3 interacts with multiple activated proteins of the tyrosine kinase signaling pathway including IGF1 receptor, insulin receptor and JAK2. SOCS3 / CIS3 could be used as a possible therapeutic agent for treating rheumatoid arthritis.

    SOCS3 References

    • Hoertner M., et al., 2002, Eur. J. Biochem. 269:2516-26.
    • Yamamoto K., et al., 2003, Biochem. Biophys. Res. Commun. 310 : 1188-93.
    • Kamura T., et al., 2004, Genes Dev. 18:3055-65.
    • Okamura A., et al., 2004, Blood 103:2997-3004.
    • Ekelund E., et al., 2006, Am. J. Hum. Genet. 78:1060-5.

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