SOCS2 Antibodies, cDNA Clones Research Reagents

SOCS2 (Suppressor Of Cytokine Signaling 2, also known as CIS2; SSI2; Cish2; SSI-2; SOCS-2; STATI2), located on 12q22, is a Protein Coding gene. The gene produces a 22172 Da protein composed of 198 amino acids. This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. The deduced amino acid sequences of human SSI2 and SSI3 share significant homology with human and mouse SSI1 (SOCS1) and mouse Cis at the C-terminal region as well as in the SH2 domain. SOCS2 acts as substrate recognition subunit of a Cullin5 E3 ubiquitin ligase complex

SOCS2 Antibody (1)

    SOCS2 cDNA Clone (30)

    SOCS2 Background

    The suppressor of cytokine signaling 2 (SOCS2) is a member of the SOCS family and influences the carcinogenesis of multiple types of tumors. SOCS2 acts as substrate recognition subunit of a Cullin5 E3 ubiquitin ligase complex. SOCS2 binds to phosphotyrosine-modified epitopes as degrons for ubiquitination and proteasomal degradation. Its deficiency is associated with gigantism and organismal lethality upon inflammatory challenge. SOCS2, a feedback inhibitor of JAK-STAT pathways, is expressed in most primitive hematopoietic stem cells (HSC) and is upregulated in response to STAT5-inducing cytokines. SOCS2 is a STAT5b-regulated gene and one of its functions is to influence growth and development through negative regulatory effects on GH/IGF-1 pathway. SOCS2 inhibited human hepatocellular carcinoma (HCC) metastasis, and SOCS2 might provide a new potential therapeutic strategy for treating HCC.

    SOCS2 References

    • Trarbach EB, et al. (2017) Socs2 polymorphisms are not associated with clinical and biochemical phenotypes in acromegalic patients. Pituitary 20 (3): 319-324.
    • Kung WW, et al. (2019) Structural insights into substrate recognition by the socs2 e3 ubiquitin ligase. Nat Commun 10 (1): 2534.
    • Cui M, et al. (2016) The suppressor of cytokine signaling 2 (socs2) inhibits tumor metastasis in hepatocellular carcinoma. Tumour Biol 37 (10): 13521-13531.
    • Bi H, et al. (2017) Increased copy number of socs2 gene in chinese gamecocks. Poult Sci 96 (5): 1041-1044.

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