SMYD3 Proteins, cDNA Clones Research Reagents

All SMYD3 reagents are produced in house and quality controlled, including 45 SMYD3 Gene, 2 SMYD3 Lysate, 2 SMYD3 Protein, 2 SMYD3 qPCR. All SMYD3 reagents are ready to use.

SMYD3 Protein (2)

    SMYD3 cDNA Clone (45)

    SMYD3 Lysate (2)

      SMYD3 Background

      SET and MYND domain-containing protein 3, also known as Zinc finger MYND domain-containing protein 1, SMYD3, and ZMYND, is a member of the histone-lysine methyltransferase family. SMYD3 contains oneMYND-type zinc finger and oneSET domain. SMYD3 is a histone H3 lysine-4-specific methyltransferase. It is expressed in skeletal muscles and testis. It is overexpressed in a majority of colorectal carcinoma (CRC) and hepatocellular carcinoma (HCC). SMYD3 plays an important role in transcriptional regulation in human carcinogenesis. It activates the transcription of a set of downstream genes. Of these downstream genes, there are several oncogenes and genes associated with cell adhesion (including those of N-Myc, CrkL, Wnt1b, L-selectin, CD31 and galectin-4), which have been shown to have effects on cell viability, adhesion, migration and metastasis. Increased SMYD3 expression is essential for the proliferation of breast cancer cells. SMYD3 may be a promising new target of therapeutic intervention for the treatment of cancers or other pathological processes associated with cell adhesion and migration.

      SMYD3 References

      • Hamamoto, R. et al., 2006, Cancer Sci. 97 (2): 113-8.
      • Luo, XG. et al., 2007, J Biosci Bioeng. 103 (5): 444-50.
      • Wang, XQ. et al., 2007, Exp Oncol. 29 (1): 71-3.
      • Silva, FP. et al., 2008, Oncogene. 27 (19): 2686-92.

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