SMYD2 Proteins, Antibodies, cDNA Clones Research Reagents

SMYD2 (SET And MYND Domain Containing 2) is a protein coding gene located on human chromosome 1q32.3. SMYD2 is also known as KMT3C, HSKM-B and ZMYND14. The human SMYD2 gene encodes a 49688 Da protein containing 433 amino acids. The SMYD2 protein is broadly expressed in heart, testis and other tissues. Among its related pathways are Lysine degradation and PKMTs methylate histone lysines. SMYD2 is related to p53 binding and protein-lysine N-methyltransferase activity. SMYD1 is an important paralog of SMYD2 gene.

SMYD2 Protein (1)

    SMYD2 Antibody (2)

      SMYD2 cDNA Clone (15)

      SMYD2 qPCR Primer (1)

      SMYD2 Lysate (1)

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        SMYD2 Background

        SET and MYND domain-containing protein 2, also known as HSKM-B, SMYD2, and KMT3C, is a member of the SMYD protein family. It contains one MYND-type zinc finger and one SET domain. Not much is known about SMYD2. However, the interest in better understanding the roles of SMYD2 has grown because of reports indicating that SMYD2 methylates p53 and histone H3. In Xenopus, SMYD1 and SMYD2 were expressed in various muscle tissues and related to muscle cell differentiation. SMYD2 mRNA is most highly expressed in heart and brain tissue. Over-expressed SMYD2 localizes to the cytoplasm and the nucleus in 293T cells. SMYD2 appears to restrain cell proliferation, likely through direct modulation of chromatin structure. Patients with SMYD2-overexpressing tumors had a worse overall rate of survival than those with non-expressing tumors, and SMYD2 positivity was independently associated with a worse outcome in the multivariate analysis. SMYD2 plays an important role in tumor cell proliferation through its activation/overexpression and regards as a prognosticator and potential therapeutic target in esophageal squamous cell carcinoma (ESCC).

        SMYD2 References

        • Zakut-Houri R., et al.,(1985), Human p53 cellular tumor antigen: cDNA sequence and expression in COS cells. EMBO J. 4:1251-1255.
        • Lamb P., et al., (1986), Characterization of the human p53 gene.Mol. Cell. Biol. 6:1379-1385.
        • Harlow E., et al.,(1985), Molecular cloning and in vitro expression of a cDNA clone for human cellular tumor antigen p53.Mol. Cell. Biol. 5:1601-1610.

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