Smad3 Proteins, Antibodies, cDNA Clones Research Reagents

All Smad3 reagents are produced in house and quality controlled, including 1 Smad3 Antibody, 30 Smad3 Gene, 1 Smad3 IP Kit, 1 Smad3 Lysate, 1 Smad3 Protein, 2 Smad3 qPCR. All Smad3 reagents are ready to use.

Smad3 Protein (1)

    Smad3 Antibody (1)

      Smad3 cDNA Clone (30)

      Smad3 Lysate (1)

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        Smad3 Background

        SMAD3 belongs to the SMAD family. Members of this family mediate signal transduction by the TGF-beta/activin/BMP-2/4 cytokine superfamily from receptor Ser/Thr protein kinases at the cell surface to the nucleus. SMAD3 is involved in cell signalling. It modulates signals of activin and TGFβ's. Binding of SMAD3 with SMAD4 enables its transmigration into the nucleus where it forms complexes with other proteins and acts as a transcription factor. SMAD3 is a receptor-regulated SMAD (R-SMAD). In mice, mutation of SMAD3 has been linked to colorectal adenocarcinoma, increased systemic inflammation, and accelerated wound healing. Increased SMAD3 activity has been implicated in the pathogenesis of scleroderma. Smad3 is also a multifaceted regulator in adipose physiology and the pathogenesis of obesity and type 2 diabetes.

        Smad3 References

        • Tan. et al., 2011, Diabetes. 60 (2): 464-76.
        • Yang X. et al., 1999, Nat Cell Biol. 1 (5): 260-6.
        • Zhu Y. et al., 1998, Cell. 94 (6): 703-14.
        • Feng X. et al., 1996, Nature. 383 (6596): 168-72.

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