SLAMF7/CD319 Proteins, Antibodies, cDNA Clones Research Reagents

SLAMF7 (SLAM Family Member 7) is a protein coding gene located on human chromosome 1q23.3. SLAMF7 is also known as 19A, CS1, CD319 and CRACC. The human SLAMF7 gene encodes a 37421 Da protein containing 335 amino acids. The SLAMF7 protein is biasedly expressed in lymph node, appendix and other tissues. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. CD84 is an important paralog of SLAMF7 gene. SLAMF7 is associated with some diseases, including Smoldering Myeloma and Submandibular Gland Disease.

SLAMF7/CD319 Protein (5)

    SLAMF7/CD319 Antibody (10)

      SLAMF7/CD319 cDNA Clone (26)

      NM_021181
      NM_144539.5

      SLAMF7/CD319 Lysate (3)

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        SLAMF7/CD319 Background

        SLAM family member 7 (SLAMF7), also known as CRACC, CD319, CD2-like receptor-activating cytotoxic cells, and CS1, is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 is expressed in NK cells, activated B-cells, NK-cell line but not in promyelocytic, B-cell lines, or T-cell lines. Although the cytoplasmic domain of CS1 contains immunoreceptor tyrosine-based switch motifs (ITSM), which enables to recruit signaling lymphocyte activation molecule (SLAM)-associated protein (SAP/SH2D1A), it activates NK cells in the absence of a functional SAP. CS1 is a self ligand and homophilic interaction of CS1 regulates NK cell cytolytic activity. CRACC positively regulated natural killer cell functions by a mechanism dependent on the adaptor EAT-2 but not the related adaptor SAP. However, in the absence of EAT-2, CRACC potently inhibited natural killer cell function. It was also inhibitory in T cells, which are typically devoid of EAT-2. Thus, CRACC can exert activating or inhibitory influences on cells of the immune system depending on cellular context and the availability of effector proteins.

        SLAMF7/CD319 References

        • Lee JK, et al. (2004) Molecular and functional characterization of a CS1 (CRACC) splice variant expressed in human NK cells that does not contain immunoreceptor tyrosine-based switch motifs. Eur J Immunol. 34(10): 2791-9.
        • Tassi I, et al. (2005) The cytotoxicity receptor CRACC (CS-1) recruits EAT-2 and activates the PI3K and phospholipase Cgamma signaling pathways in human NK cells. J Immunol. 175(12): 7996-8002.
        • Lee JK, et al. (2007) CS1 (CRACC, CD319) induces proliferation and autocrine cytokine expression on human B lymphocytes. J Immunol. 179(7): 4672-8.
        • Cruz-Munoz ME, et al. (2009) Influence of CRACC, a SLAM family receptor coupled to the adaptor EAT-2, on natural killer cell function. Nat Immunol. 10(3): 297-305.

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