SIRT6 Antibodies, cDNA Clones Research Reagents

SIRT6 (Sirtuin 6) is a protein coding gene located on human chromosome 19p13.3. SIRT6 is also known as SIR2L6. The human SIRT6 gene encodes a 39119 Da protein containing 355 amino acids. The SIRT6 protein is ubiquitously expressed in colon, spleen and other tissues. Among its related pathways are Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins, and NAD metabolism. SIRT6 is related to chromatin binding and NAD-dependent histone deacetylase activity (H3-K9 specific). SIRT7 is an important paralog of SIRT6 gene. SIRT6 is associated with some diseases, including Mood Disorder and Monckeberg Arteriosclerosis.

SIRT6 Antibody (2)

    SIRT6 cDNA Clone (16)


    In expression vector

    SIRT6 qPCR Primer (1)

    SIRT6 Background

    Sirtuin 6 (SIRT6) is a nicotinamide adenine dinucleotide(+) (NAD(+)) dependent enzyme and stress response protein. SIRT6 has several different functions in multiple different molecular pathways related to DNA repair, glycolysis, gluconeogenesis, tumorigenesis, neurodegeneration, cardiac hypertrophic responses, and more. SIRT6 is a main regulator of metabolism and lifespan and its importance has been implicated in the prevention against aging-related diseases. SIRT6 depletion enhanced chemosensitivity of human hepatoma cells by downregulating MDR1 expression through suppressing C/EBPbeta. SIRT6 may serve as a novel target to enhance chemosensitivity in HCC cells.

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