SIRP alpha Proteins, Antibodies, cDNA Clones Research Reagents

SIRPA (Signal Regulatory Protein Alpha) is a protein coding gene located on human chromosome 20p13. SIRPA is also known as BIT, MFR, P84, SIRP, MYD-1, SHPS1, CD172A and PTPNS1. The human SIRPA gene encodes a 54967 Da protein containing 504 amino acids. The SIRPA protein is ubiquitously expressed in brain, appendix and other tissues. Among its related pathways are Cell surface interactions at the vascular wall and Tyrosine Kinases / Adaptors. SIRPA is related to SH3 domain binding. SIRPB1 is an important paralog of SIRPA gene. SIRPA is associated with some diseases, including Suppression Amblyopia and Bladder Neck Obstruction.

SIRP alpha Protein (16)

    SIRP alpha Antibody (23)

      SIRP alpha cDNA Clone (27)


      In expression vector


      SIRP alpha Lysate (11)

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        SIRP alpha Background

        Tyrosine-protein phosphatase non-receptor type substrate 1, also known as SHP substrate 1, Inhibitory receptor SHPS-1, Brain Ig-like molecule with tyrosine-based activation motifs, Macrophage fusion receptor, CD172 antigen-like family member A, SIRPA and CD172a, is a single-pass type I membrane protein which contains two Ig-like C1-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. SIRPA is ubiquitously expressed. It is highly expressed in brain and detected at lower levels in heart, placenta, lung, testis, ovary, colon, liver, small intestine, prostate, spleen, kidney, skeletal muscle and pancreas. It is also detected on myeloid cells, but not T-cells. SIRPA is an immunoglobulin-like cell surface receptor for CD47. SIRPA acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. SIRPA supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. It may play a key role in intracellular signaling during synaptogenesis and in synaptic function. SIRPA is involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. It mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation.

        SIRP alpha References

        • Timms JF. et al., 1999, Curr Biol. 9: 927-30.
        • Stofega MR. et al., 2000, J Biol Chem. 275: 28222-9.
        • Liu T. et al., 2005, J Proteome Res. 4: 2070-80.
        • Wolf-Yadlin A. et al., 2007, Proc Natl Acad Sci. 104: 5860-5.

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