SIGIRR Proteins, Antibodies, cDNA Clones Research Reagents

SIGIRR (Single Ig And TIR Domain Containing) is a protein coding gene located on human chromosome 11p15.5. SIGIRR is also known as TIR8 and IL-1R8. The human SIGIRR gene encodes a 45679 Da protein containing 410 amino acids. The SIGIRR protein is ubiquitously expressed in spleen, kidney and other tissues. Among its related pathways are Activated TLR4 signalling and Innate Immune System. IL1RAPL2 is an important paralog of SIGIRR gene. SIGIRR is associated with some diseases, including Central Nervous System Tuberculosis and Progressive Myoclonus Epilepsy 8.

SIGIRR Protein (3)

    SIGIRR Antibody (6)

      SIGIRR cDNA Clone (39)

      BC003591
      NM_023059.3
      XM_004781062.1

      SIGIRR Lysate (3)

        SIGIRR Background

        Single Ig IL-1-related receptor (SIGIRR) or TIR8 is a member of Toll-like receptor-interleukin 1 receptor signaling (TLR-IL-1R) receptor superfamily. Although SIGIRR/TIR8 shows the typical conserved motifs that characterize the IL-1R and Toll superfamily, it is structurally and functionally distinct from both. SIGIRR/TIR8 has only one Ig domain in its extracellular portion whereas the IL-1R family contains three Ig folds. An unusually long cytoplasmic domain is reminiscent of the structure of drosophila Toll, yet the SIGIRR peptide sequence is more closely related to IL-1RI. SIGIRR/TIR8 was mainly expressed in mouse and human epithelial tissues such as kidney, lung and gut. Resting and activated T and B lymphocytes and monocytes-macrophages expressed little or no SIGIRR/TIR8, with the exception of the mouse GG2EE macrophage line. Inflammation is enhanced in SIGIRR-deficient mice. SIGIRR negatively modulates immune responses. Inflammation is enhanced in SIGIRR-deficient mice, as shown by their enhanced chemokine induction after IL-1 injection and reduced threshold for lethal endotoxin challenge.

        SIGIRR References

        • Wald D, et al. (2003) SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling. Nat Immunol. 4(9): 920-7.
        • Polentarutti N, et al. (2003) Unique pattern of expression and inhibition of IL-1 signaling by the IL-1 receptor family member TIR8/SIGIRR. Eur Cytokine Netw. 14(4): 211-8.
        • Wald D, et al. (2003) SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling. Nat Immunol. 4(9): 920-7.

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