SFTPA1 Antibodies, cDNA Clones Research Reagents

SFTPA1 (Surfactant Protein A1, also known as SPA; PSAP; PSPA; SPA1; SFTP1; COLEC4; SFTPA1B; SP-A1 beta; SP-A1 delta; SP-A1 gamma; SP-A1 epsilon), located on 10q22.3, is a Protein Coding gene. This gene encodes a lung surfactant protein that is a member of a subfamily of C-type lectins called collectins. The gene produces a 26242 Da protein composed of 248 amino acids. SFTPA1 variants differ in their ability to regulate the AM miRNome in response to oxidative stress (OxS). Diseases such as Pulmonary Fibrosis and Pulmonary Fibrosis, Idiopathic are associated with SFTPA1.

SFTPA1 Antibody (1)

    SFTPA1 cDNA Clone (26)

    NM_001164647.1
    NM_017329.2

    SFTPA1 Background

    Surfactant protein A (SFTPA1), a member of the collagenous lectin (collectin) family, was first described as a major constituent of lung surfactant but has recently also been found in the female genital tract. Various microorganisms colonize this area and may cause intrauterine infection or trigger preterm labor. The human SFTPA1 and SFTPA2 genes encode SP-A1 and SP-2 proteins, and each gene has been identified with numerous genetic variants. SP-A1 and SP-A2 differentially enhance bacterial phagocytosis. Sex differences have been observed in pulmonary disease and survival of wild type and SP-A knockout (KO) mice. SP-A interacts and regulates many of the functions of alveolar macrophages (AM). It is shown that SP-A variants differ in their ability to regulate the AM miRNome in response to oxidative stress (OxS).

    SFTPA1 References

    • Thorenoor N, et al. (2019) Differential impact of co-expressed sp-a1/sp-a2 protein on am mirnome; sex differences. Front Immunol 10 1960.
    • Thorenoor N, et al. (2018) Survival of surfactant protein-a1 and sp-a2 transgenic mice after klebsiella pneumoniae infection, exhibits sex-, gene-, and variant specific differences; treatment with surfactant protein improves survival. Front Immunol 9 2404.
    • Garcia-Verdugo I, et al. (2007) Direct interaction of surfactant protein a with myometrial binding sites: Signaling and modulation by bacterial lipopolysaccharide. Biol Reprod 76 (4): 681-691.

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