SETD7 Proteins, Antibodies, cDNA Clones Research Reagents

All SETD7 reagents are produced in house and quality controlled, including 5 SETD7 Antibody, 16 SETD7 Gene, 1 SETD7 IP Kit, 1 SETD7 Protein, 1 SETD7 qPCR. All SETD7 reagents are ready to use.

SETD7 Protein (1)

    SETD7 Antibody (5)

      SETD7 cDNA Clone (16)

      NM_080793.5

      In expression vector

      SETD7 qPCR Primer (1)

      SETD7 Background

      Histone-lysine N-methyltransferase SETD7, also known as SET domain containing (lysine methyltransferase) 7, SET7/9, Histone H3-K4 methyltransferase SETD7, H3-K4-HMTase SETD7, and SETD7, is a member of thehistone-lysine methyltransferase family and SET7 subfamily. SETD7 is widely expressed and expressed in pancreatic islets. SETD7 contains three MORN repeats and one SET domain. SETD7 plays a central role in the transcriptional activation of genes such as collagenase or insulin. As a protein lysine methyltransferase (PKMT), SETD7 also has methyltransferase activity toward non-histone proteins such as p53/TP53, TAF1, and possibly TAF7 by recognizing and binding in substrate proteins. The mono-methyltransferase activity of SETD7 is achieved by disrupting the formation at near-attack conformations for the dimethylation reaction. SETD7 is also a novel coactivator of NF-kappaB and plays a role in inflammation and diabetes.

      SETD7 References

      • Wang, H. et al., 2002, Mol Cell 8 (6): 1207-17. 
      • Jacobs, SA. et al., 2002, Nat. Struct. Biol. 9 (11): 833-8. 
      • Xiao B, et al., 2003, Nature. 421 (6923): 652-6.
      • Martens, JH. et al., 2003, Mol. Cell. Biol. 23: 1808-1816.
      • Couture, JF. et al., 2006, Nat Struct Mol Biol  13 (2): 140-6.

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