SETD7 Proteins, Antibodies, cDNA Clones Research Reagents

SETD7 (SET Domain Containing 7, Histone Lysine Methyltransferase) is a protein coding gene located on human chromosome 4q31.1. SETD7 is also known as KMT7, SET7, SET9 and SET7/9. The human SETD7 gene encodes a 40721 Da protein containing 366 amino acids. The SETD7 protein is ubiquitously expressed in fat, prostate and other tissues. Among its related pathways are Lysine degradation and PKMTs methylate histone lysines. SETD7 is related to p53 binding and protein-lysine N-methyltransferase activity. RSPH10B is an important paralog of SETD7 gene.

SETD7 Protein (1)

    SETD7 Antibody (5)

      SETD7 cDNA Clone (16)


      In expression vector

      SETD7 qPCR Primer (1)

      SETD7 Background

      Histone-lysine N-methyltransferase SETD7, also known as SET domain containing (lysine methyltransferase) 7, SET7/9, Histone H3-K4 methyltransferase SETD7, H3-K4-HMTase SETD7, and SETD7, is a member of the histone-lysine methyltransferase family and SET7 subfamily. SETD7 is widely expressed and expressed in pancreatic islets. SETD7 contains three MORN repeats and one SET domain. SETD7 plays a central role in the transcriptional activation of genes such as collagenase or insulin. As a protein lysine methyltransferase (PKMT), SETD7 also has methyltransferase activity toward non-histone proteins such as p53/TP53, TAF1, and possibly TAF7 by recognizing and binding in substrate proteins. The mono-methyltransferase activity of SETD7 is achieved by disrupting the formation at near-attack conformations for the dimethylation reaction. SETD7 is also a novel coactivator of NF-kappaB and plays a role in inflammation and diabetes.

      SETD7 References

      • Wang, H. et al., 2002, Mol Cell 8 (6): 1207-17. 
      • Jacobs, SA. et al., 2002, Nat. Struct. Biol. 9 (11): 833-8. 
      • Xiao B, et al., 2003, Nature. 421 (6923): 652-6.
      • Martens, JH. et al., 2003, Mol. Cell. Biol. 23: 1808-1816.
      • Couture, JF. et al., 2006, Nat Struct Mol Biol  13 (2): 140-6.

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