Alpha 2 Antiplasmin/SerpinF2 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All Alpha 2 Antiplasmin/SerpinF2 reagents are produced in house and quality controlled, including 12 Alpha 2 Antiplasmin/SerpinF2 Antibody, 4 Alpha 2 Antiplasmin/SerpinF2 ELISA, 39 Alpha 2 Antiplasmin/SerpinF2 Gene, 2 Alpha 2 Antiplasmin/SerpinF2 IP Kit, 3 Alpha 2 Antiplasmin/SerpinF2 Lysate, 3 Alpha 2 Antiplasmin/SerpinF2 Protein, 3 Alpha 2 Antiplasmin/SerpinF2 qPCR. All Alpha 2 Antiplasmin/SerpinF2 reagents are ready to use.

All Alpha 2 Antiplasmin/SerpinF2 Reagents

Alpha 2 Antiplasmin/SerpinF2 Protein (3)

    Alpha 2 Antiplasmin/SerpinF2 Antibody (12)

      Alpha 2 Antiplasmin/SerpinF2 ELISA Kit & Match Antibody ELISA Pair Set (4)

      Alpha 2 Antiplasmin/SerpinF2 cDNA Clone (39)

      NM_000934.3
      NM_008878.1
      NM_001011892.1

      Alpha 2 Antiplasmin/SerpinF2 Lysate (3)

        Alpha 2 Antiplasmin/SerpinF2 Background

        SerpinF2, also known as alpha-2 antiplasmin (alpha-2 AP), is a member of the Serpin superfamily. SerpinF2 is the principal physiological inhibitor of serine protease plasmin, and as well as, an efficient inhibitor of trypsin and chymotrypsin. This protease is produced mainly by liver and kidney, and also expressed in muscle, intestine, central nervous system, and placenta also express this protein at a moderate level. It is indicated that Serpin F2 is a key regulator of plasmin-mediated proteolysis in these tissues. Alpha-2 AP is an unusual serpin in that it contains extensive N- and C-terminal sequences flanking the serpin domain. The N-terminal sequence is crosslinked to fibrin by factor XIIIa, whereas the C-terminal region mediates the initial interaction with plasmin. SerpinF2 is one of the inhibitors of fibrinolysis, which acts as the primary inhibitor of plasmin(ogen). It is a specific plasmin inhibitor, and is important in modulating the effectiveness and persistence of fibrin with respect to its susceptibility to digestion and removal by plasmin. Alpha-2 AP plays the dominant role in inhibiting both plasma clot lysis and thrombus lysis, and accordingly, the congenital deficiency of Alpha-2 antiplasmin causes a rare bleeding disorder because of increased fibrinolysis. Thus, it may be a useful target for developing more effective treatment of thrombotic diseases.

        Alpha 2 Antiplasmin/SerpinF2 References

        • Lee KN, et al. (2004) Alpha2-antiplasmin: potential therapeutic roles in fibrin survival and removal. Curr Med Chem Cardiovasc Hematol Agents. 2(4): 303-10.
        • Matsuno H. (2006) Alpha2-antiplasmin on cardiovascular diseases. Curr Pharm Des. 12(7): 841-7.
        • Burnouf T, et al. (2007) Impact of Triton X-100 on alpha 2-antiplasmin (SERPINF2) activity in solvent/detergent-treated plasma. Biologicals. 35(4): 349-53.
        • Carpenter SL, et al. (2008) Alpha2-antiplasmin and its deficiency: fibrinolysis out of balance. Haemophilia. 14(6): 1250-4.

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