SerpinB8 Proteins, Antibodies, cDNA Clones Research Reagents

SERPINB8 (Serpin Family B Member 8) is a protein coding gene located on human chromosome 18q22.1. SERPINB8 is also known as PI8, CAP2, PI-8, PSS5, and C18orf53. The human SERPINB8 gene encodes a 42767 Da protein containing 374 amino acids. The SERPINB8 protein is ubiquitously expressed in skin, gall bladder and other tissues. Among its related pathways are Dissolution of Fibrin Clot and Response to elevated platelet cytosolic Ca2+. SERPINB8 is related to serine-type endopeptidase inhibitor activity. SERPINB6 is an important paralog of SERPINB8 gene. SERPINB8 is associated with some diseases, including Peeling Skin Syndrome 5 and Exfoliative Ichthyosis.

SerpinB8 Protein (1)

    SerpinB8 Antibody (3)

      SerpinB8 cDNA Clone (30)

      SerpinB8 Lysate (1)

        SerpinB8 Background

        Serpins are the largest and most diverse family of serine protease inhibitors which are involved in a number of fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, inflammation and tumor suppression and are expressed in a cell-specific manner.
        Mouse SerpinB8, also known as Cytoplasmic antiproteinase 2, Peptidase inhibitor 8, SerpinB8, PI-8, SERPINB8 and CAP2, is a member of the Serpin superfamily. SERPINB8 was broadly expressed. In normal neuroendocrine tissues, strongest SerpinB8 expression was detected in islets of Langerhans of the pancreas. Moderate SerpinB8 expression was observed in neuroendocrine cells of the thyroid, adrenal cortex, colon, and pituitary gland. In the pancreas, SerpinB8 is specifically expressed by insulin-producing beta cells, and can be used as an additional diagnostic immunohistochemical marker. Mouse SerpinB8 distribution alters during kidney regeneration, possibly to control a prohormone convertase involved in inflammation or tissue repair.

        SerpinB8 References

        • Sumi, Y. et al., 1989, J. Biochem. 106: 703-7.
        • Rawlings, N.D. et al., 2004, Biochem J. 378: 705-16.
        • Gillard, A. et al., 2006, Am J Nephrol. 26 (1): 34-42.
        • Filleur, S. et al., 2009, J Cell Biochem. 106 (5): 769-75.
        • de Koning, P.J. et al., 2009, Pancreas. 38 (4): 461-7.

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