SERPINB10 Proteins, Antibodies, cDNA Clones Research Reagents

SERPINB10 (Serpin Family B Member 10) is a protein coding gene located on human chromosome 18q22.1. SERPINB10 is also known as PI10 and PI-10. The human SERPINB10 gene encodes a 45403 Da protein containing 397 amino acids. The SERPINB10 protein is restrictedly expressed toward bone marrow. Among its related pathways are Innate Immune System and Amoebiasis. SERPINB10 is related to serine-type endopeptidase inhibitor activity. SERPINB2 is an important paralog of SERPINB10 gene. SERPINB10 is associated with some diseases, including Chronic Myelomonocytic Leukemia and Cardiomyopathy, Familial Hypertrophic, 1.

SERPINB10 Protein (1)

    SERPINB10 Antibody (2)

      SERPINB10 cDNA Clone (16)


      In expression vector

      SERPINB10 qPCR Primer (1)

      SERPINB10 Lysate (1)

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        SERPINB10 Background

        Serpins are the largest and most diverse family of serine protease inhibitors which are involved in a number of fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, inflammation and tumor suppression and are expressed in a cell-specific manner. Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. The acronym serpin was originally coined because many serpins inhibit chymotrypsin-like serine proteases (serine protease inhibitors). Over 1 serpins have been identified.
        Mouse SerpinB1, also known as Peptidase inhibitor 1, PI-1, Bomapin and SERPINB1, is a nucleus and cytoplasm protein that belongs to the serpin family and Ov-serpin subfamily. SerpinB1 is expressed specifically in the bone marrow. SerpinB1 is a protease inhibitor that may play a role in the regulation of protease activities during hematopoiesis and apoptosis induced by TNF. SerpinB1 is a redox-sensitive nuclear serpin that augments proliferation or apoptosis of leukaemia cells, depending on growth factors availability. SerpinB1 may regulate protease activities in the cytoplasm and the nucleus.

        SERPINB10 References

        • Riewald M. et al., 1995, J. Biol. Chem. 270: 26754-7.
        • Forsyth, S. et al., 2003, Genomics 81: 336-45. 
        • Horvath, AJ. et al., 2004, J. Mol. Evol. 59: 488-97.
        • Steenbakkers PJ. et al., 2008, Mycol. Res. 112 (Pt 8): 999-1006.
        • Przygodzka, P. et al., 2010, BMC Cell Biol. 11: 30. 

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