Semaphorin 4D Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

SEMA4D (Semaphorin 4D) is a protein coding gene located on human chromosome 9q22.2. SEMA4D is also known as A8, GR3, BB18, CD100, COLL4, SEMAJ, coll-4, C9orf164 and M-sema-G. The human SEMA4D gene encodes a 96150 Da protein containing 862 amino acids. The SEMA4D protein is broadly expressed in lymph node, appendix and other tissues. Among its related pathways are Guidance Cues and Growth Cone Motility and Axon guidance. SEMA4D is related to signaling receptor binding and transmembrane signaling receptor activity. SEMA4C is an important paralog of SEMA4D gene. SEMA4D is associated with some diseases, including Autoimmune Vasculitis and Osteonecrosis Of The Jaw.

Semaphorin 4D Protein (6)

    Semaphorin 4D Antibody (19)

      Semaphorin 4D ELISA Kit & Match Antibody ELISA Pair Set (1)

      Semaphorin 4D cDNA Clone (41)


      In expression vector

      In lentiviral vector


      Semaphorin 4D Lysate (6)

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        Semaphorin 4D Background

        Semaphorin 4D (SEMA4D or CD100) is a member of the semaphorin family of proteins and an important mediator of the movement and differentiation of multiple cell types, including those of the immune, vascular, and nervous systems. VEGF and SEMA4D had a positive correlation with the malignant degree of ovarian cancer, and SEMA4D can serve as an independent prognostic factor. SEMA4D was the first semaphorin described to have immune functions and serves important roles in T cell priming, antibody production, and cell-to-cell adhesion. Proteolytic cleavage of SEMA4D from the cell surface gives rise to a soluble fragment of SEMA4D (sSEMA4D). Similar to the transmembranal form, sSEMA4D is thought to have immunoregulatory properties.

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