S6K1/RPS6KB1 Proteins, Antibodies, cDNA Clones Research Reagents

RPS6KB1 (Ribosomal Protein S6 Kinase B1) is a protein coding gene located on human chromosome 17q23.1. RPS6KB1 is also known as S6K, PS6K, S6K1, STK14A, p70-S6K, p70 S6KA, p70-alpha, S6K-beta-1 and p70(S6K)-alpha. The human RPS6KB1 gene encodes a 59140 Da protein containing 525 amino acids. The RPS6KB1 protein is ubiquitously expressed in esophagus, thyroid and other tissues. Among its related pathways are Common Cytokine Receptor Gamma-Chain Family Signaling Pathways and Translation Translation regulation by Alpha-1 adrenergic receptors. RPS6KB1 is related to transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. RPS6KB2 is an important paralog of RPS6KB1 gene. RPS6KB1 is associated with some diseases, including Tuberous Sclerosis and Lymphangioleiomyomatosis.

S6K1/RPS6KB1 Protein (1)

    S6K1/RPS6KB1 Antibody (3)

      S6K1/RPS6KB1 cDNA Clone (32)

      NM_031985.1

      In cloning vector

      In lentiviral vector

      S6K1/RPS6KB1 qPCR Primer (1)

      S6K1/RPS6KB1 Lysate (1)

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        S6K1/RPS6KB1 Background

        PS6K, also known as RPS6KB1, is a serine/threonine-protein kinase. It belongs to the RSK (ribosomal s6 kinase) family. Members of this family function in signal transduction. PS6K is an isoform of p70 ribosomal S6 kinase (S6K). S6K can be activated by mitogenic stimuli such as growth factors, insulin and cytokines. It phosphorylates the ribosomal protein S6. PS6K also phosphorylates other proteins such as elF4B, eEF2K and SKAR. It is a crucial effector of mTOR(rapamycin) signaling. PS6K is dissociated from the EIF3 complex and activated upon mitogenic stimulation, phosphorylation by the mammalian target of mTOR complex 1 (mTORC1). Its active form then phosphorylates and activates several substrates in the preinitiation complex, including the EIF2B complex and the cap-binding complex component EIF4B. PS6K also functions in cell proliferation, cell growth and cell cycle progression.

        S6K1/RPS6KB1 References

        • Panasyuk, et al. (2006) Nuclear export of PS6K II is regulated by protein kinase CK2 phosphorylation at Ser-17. J Biol Chem. 281(42):31188-201.
        • Carnevalli L, et al. (2010) PS6K Plays a Critical Role in Early Adipocyte Differentiation. Dev Cell. 18 (5):763-74.
        • Grove JR, et al. (1991) Cloning and expression of two human p70 S6 kinase polypeptides differing only at their amino termini. Mol Cell Biol. 11(11):5541-50.

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