S100A11 Proteins, Antibodies, cDNA Clones Research Reagents

S100A11 (S100 Calcium Binding Protein A11) is a protein coding gene located on human chromosome 1q21.3. S100A11 is also known as MLN70, S100C and HEL-S-43. The human S100A11 gene encodes a 11740 Da protein containing 105 amino acids. The S100A11 protein is broadly expressed in esophagus, placenta and other tissues. Among its related pathways are Innate Immune System. S100A11 is related to calcium ion binding and calcium-dependent protein binding. S100A1 is an important paralog of S100A11 gene. S100A11 is associated with some diseases, including Dry Eye Syndrome and Infective Endocarditis.

S100A11 Protein (2)

    S100A11 Antibody (5)

      S100A11 cDNA Clone (45)

      S100A11 Background

      Protein S100-A11, also known as S100 calcium-binding protein A11, S100A11 and MLN70, is a member of theS-100 family. S100A11 is widely expressed in multiple tissues, and is located in cytoplasm, nucleus, and even cell periphery. S100A11 exists as a non-covalent homodimer with an antiparallel conformation. Ca(2+) binding to S100A11 would trigger conformational changes which would expose the hydrophobic cleft of S100A11 and facilitate its interaction with target proteins. As a dual cell growth mediator, S100A11 acts as either a tumor suppressor or promoter in many different types of tumors and would play respective roles in influencing the proliferation of the cancer cells. In the nucleus, S100A11 suppresses the growth of keratinocytes through p21 (CIP1/WAF1) activation and induces cell differentiation. S100A11 is also a novel diagnostic marker in breast carcinoma.

      S100A11 References

      • Miyasaki KT. et al., 1993, J Dent Res. 72: 517-23.
      • Ohuchida K. et al., 2006, Clin Cancer Res  12 (18): 5417-22.
      • Kouno T. et al., 2008, J Pept Sci. 14 (10): 1129-38.
      • He H. et al., 2009, Cell Biochem Biophys 55 (3): 117-26.
      • Liu XG. et al., 2010, Oncol Rep. 23 (5): 1301-8.

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