S100A1 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

S100A1 (S100 Calcium Binding Protein A1) is a protein coding gene located on human chromosome 1q21.3. S100A1 is also known as S100, S100A and S100-alpha. The human S100A1 gene encodes a 10546 Da protein containing 94 amino acids. The S100A1 protein is biasedly expressed in heart, salivary gland other tissues. Among its related pathways are Activated TLR4 signalling and Innate Immune System. S100A1 is related to calcium ion binding and identical protein binding. S100B is an important paralog of S100A1 gene. S100A1 is associated with some diseases, including Epidermoid Cysts and Myoepithelioma.

S100A1 Protein (3)

    S100A1 Antibody (6)

      S100A1 ELISA Kit & Match Antibody ELISA Pair Set (1)

      S100A1 cDNA Clone (30)

      S100A1 Lysate (1)

        More Product Popular With Customers

        S100A1 Background

        S100A1 is a Ca2+ binding protein of the EF-hand type that belongs to the S100 protein family. S100 proteins consisting of at least 19 members exist as dimers in the cytoplasm and/or nucleus of a wide range of cells, and are involved in the regulation of a number of cellular processes such as cell-cycle progression and cell differentiation. This protein has been shown to function in the processes including stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of PKC-mediated phosphorylation. Phosphoglucomutase is a target protein whose activity is antagonistically regulated by S100A1, and recently, S100A1 is also identified as a potent molecular chaperone and a new member of the Hsp70/Hsp90 multichaperone complex. S100A1 displays a tissue-specific expression pattern with highest levels in myocardium and is considered to be an important regulator of cardiac contractility. Accordingly, reduced expression or mutations of S100A1 gene have been implicated in cardiomyopathies.

        S100A1 References

        • Remppis, A .et al., 1996, Biochim. Biophs. Acta. 1313: 253-257.
        • Most, P. et al., 2001, Proc. Natl. Acad. Sci. U.S.A. 98: 13889-13894
        • Okada, M. et al., 2004, J. Biol. Chem. 279: 4221-4233.
        • Schafer, W.E. et al., 1995, Genomics. 25: 638-643.
        • Landar, A. et al., 1996, Cell. Calcium. 20: 279-285.

        Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.