RSK4 Proteins, cDNA Clones Research Reagents

All RSK4 reagents are produced in house and quality controlled, including 15 RSK4 Gene, 1 RSK4 Lysate, 1 RSK4 Protein, 1 RSK4 qPCR. All RSK4 reagents are ready to use.

RSK4 Protein (1)

    RSK4 cDNA Clone (15)

    RSK4 qPCR Primer (1)

    RSK4 Lysate (1)

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      RSK4 Background

      Ribosomal protein S6 kinase alpha-6, also known as Ribosomal S6 kinase 4, 9 kDa ribosomal protein S6 kinase 6,RSK-4, RSK4 and RPS6KA6, is a protein which belongs to theprotein kinase superfamily, AGC Ser/Thr protein kinase family and S6 kinase subfamily. RPS6KA6 contains oneAGC-kinase C-terminal domain and twoprotein kinase domains. RPS6KA6 forms a complex with either ERK1 or ERK2 in quiescent cells. RPS6KA6 shows a high level of homology to three isolated members of the human RSK family. RSK2 is involved in Coffin-Lowry syndrome and nonspecific MRX. The localization of RPS6KA6 in the interval that is commonly deleted in mentally retarded males together with the high degree of amino acid identity with RSK2 suggests that RPS6KA6 plays a role in normal neuronal development. Further mutation analyses in males with X-linked mental retardation must prove that the gene of RPS6KA6 is indeed a novel MRX gene. RPS6KA6 is a serine/threonine kinase that may play a role in mediating the growth-factor and stress induced activation of the transcription factor CREB. RPS6KA6 is activated by multiple phosphorylations on threonine and serine residues.

      RSK4 References

      • Yntema H.G., et al.,(1999), A novel ribosomal S6-kinase (RSK4; RPS6KA6) is commonly deleted in patients with complex X-linked mental retardation. Genomics 62:332-343.
      • Ross M.T., et al., (2005), The DNA sequence of the human X chromosome.Nature 434:325-337.
      • Ota T., et al.,(2004), Complete sequencing and characterization of 21,243 full-length human cDNAs.Nat. Genet. 36:40-45.

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