RNASET2 Proteins, cDNA Clones Research Reagents

RNASET2 (Ribonuclease T2) is a protein coding gene located on human chromosome 6q27. RNASET2 is also known as RNASE6PL and bA514O12.3. The human RNASET2 gene encodes a 29481 Da protein containing 256 amino acids. The RNASET2 protein is broadly expressed in spleen, colon and other tissues. Among its related pathways are Innate Immune System. RNASET2 is related to RNA binding and endoribonuclease activity. ENSG00000249141 is an important paralog of RNASET2 gene. RNASET2 is associated with some diseases, including Leukoencephalopathy, Cystic, Without Megalencephaly and Pseudo-Torch Syndrome 1.

RNASET2 Protein (1)

    RNASET2 cDNA Clone (13)


    RNASET2 qPCR Primer (1)

    RNASET2 Lysate (1)

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      RNASET2 Background

      RNASET2 (ribonuclease T2) is an enzyme that belongs to the RNase T2 family. It is highly expressed in the temporal lobe and fetal brain. RNASET2 gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement. Defects in RNASET2 are the cause of leukoencephalopathy cystic without megalencephaly. An infantile-onset syndrome of cerebral leukoencephalopathy. Affected newborns develop microcephaly and neurologic abnormalities including psychomotor impairment, seizures and sensorineural hearing impairment. The brain shows multifocal white matter lesions, anterior temporal lobe subcortical cysts, pericystic abnormal myelination, ventriculomegaly and intracranial calcifications.

      RNASET2 References

      • Acquati F, et al. (2011) A Molecular signature induced by RNASET2, a tumor antagonizing gene, in ovarian cancer cells. Oncotarget. 2(6):477-84.
      • Campomenosi P, et al. (2011) Comparison of the baculovirus-insect cell and Pichia pastoris heterologous systems for the expression of the human tumor suppressor protein RNASET2. Biotechnol Appl Biochem. 58(1):39-49.
      • Monti L, et al. (2008) RNASET2 as a tumor antagonizing gene in a melanoma cancer model. Oncol Res. 17(2):69-74.

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