Ribonuclease A Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All Ribonuclease A reagents are produced in house and quality controlled, including 3 Ribonuclease A Antibody, 1 Ribonuclease A ELISA, 26 Ribonuclease A Gene, 1 Ribonuclease A Lysate, 1 Ribonuclease A Protein, 1 Ribonuclease A qPCR. All Ribonuclease A reagents are ready to use.

Ribonuclease A Protein (1)

    Ribonuclease A Antibody (3)

      Ribonuclease A ELISA Kit & Match Antibody ELISA Pair Set (1)

      Ribonuclease A cDNA Clone (26)

      BC005324
      NM_011271.2

      Ribonuclease A qPCR Primer (1)

      Ribonuclease A Lysate (1)

        Ribonuclease A Background

        RNase A, also known as ribonuclease A and RNASE1, belongs to ribonuclease A superfamily. It is a pancreatic-type of secretory ribonuclease. RNase A is a basic protein and its many positive charges are consistent with its binding to RNA (a poly-anion). More generally, RNase A is unusually polar or, rather, unusually lacking in hydrophobic groups, especially aliphatic ones. As a endonuclease, RNase A cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.. RNase A is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.

        Ribonuclease A References

        • Tubert P, et al. (2011) Interactions crucial for three-dimensional domain swapping in the HP-RNase variant PM8. Biophys J. 101(2):459-67.
        • Vinayagam A, et al. (2011) A directed protein interaction network for investigating intracellular signal transduction. Sci Signal. 4(189):rs8.
        • Fischer S, et al. (2011) Expression and localisation of vascular ribonucleases in endothelial cells. Thromb Haemost. 105(2):345-55.

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