RELT/TNFRSF19L Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

RELT (RELT TNF Receptor) is a protein coding gene located on human chromosome 11q13.4. RELT is also known as AI3C, TRLT and TNFRSF19L. The human RELT gene encodes a 46092 Da protein containing 430 amino acids. The RELT protein is biasedly expressed in bone marrow, spleen and other tissues. Among its related pathways are TNF Superfamily - Human Ligand-Receptor Interactions and their Associated Functions and PEDF Induced Signaling. TNFRSF1B is an important paralog of RELT gene. RELT is associated with some diseases, including Amelogenesis Imperfecta, Type Iiic and Hypoplastic Amelogenesis Imperfecta.

RELT/TNFRSF19L Protein (2)

    RELT/TNFRSF19L Antibody (5)

      RELT/TNFRSF19L ELISA Kit & Match Antibody ELISA Pair Set (1)

      RELT/TNFRSF19L cDNA Clone (39)

      NM_032871.3
      NM_177073.6
      NM_001108495.1

      RELT/TNFRSF19L Lysate (2)

        RELT/TNFRSF19L Background

        Receptor expressed in lymphoid tissues (RELT), also known as tumor necrosis factor receptor superfamily, member 19-like (TNFRSF19L), is a member of the TNF-receptor superfamily. This receptor is especially abundant in hematologic tissues. It has been shown to activate the NF-kappaB pathway and selectively bind TNF receptor-associated factor 1. RELT/TNFRSF19L is capable of stimulating T-cell proliferation in the presence of CD3 signaling, which suggests its regulatory role in immune response. RELT/TNFRSF19L is a type I transmembrane glycoprotein with a cysteine-rich extracellular domain, possessing significant homology to other members of the TNFR superfamily, especially TNFRSF19, DR3, OX40, and LTbeta receptor. RELT/TNFRSF19L is able to activate the NF-kappaB pathway and selectively binds tumor necrosis factor receptor-associated factor 1. RELT/TNFRSF19L is able to activate the NF-κB pathway and selectively binds tumor necrosis factor receptor-associated factor 1. Although the soluble form of RELT fusion protein does not inhibit the one-way mixed lymphocyte reaction, immobilized RELT/TNFRSF19L is capable of costimulating T-cell proliferation in the presence of CD3 signaling.

        RELT/TNFRSF19L References

        • Sica GL, et al. (2001) RELT, a new member of the tumor necrosis factor receptor superfamily, is selectively expressed in hematopoietic tissues and activates transcription factor NF-kappaB. Blood. 97(9): 2702-7.
        • Polek TC, et al. (2006) The TNF receptor, RELT, binds SPAK and uses it to mediate p38 and JNK activation. Biochem Biophys Res Commun. 343(1): 125-34.
        • Cusick JK, et al. (2006) Identification of RELT homologues that associate with RELT and are phosphorylated by OSR1. Biochem Biophys Res Commun. 340(2): 535-43.

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