REG4 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

REG4 (Regenerating Family Member 4) is a protein coding gene located on human chromosome 1p12. REG4 is also known as GISP, RELP and REG-IV. The human REG4 gene encodes a 18230 Da protein containing 158 amino acids. The REG4 protein is biasedly expressed in small intestine, colon and other tissues. Among its related pathways are Gastric cancer and Adhesion. REG4 is related to calcium ion binding and heparin binding. REG3A is an important paralog of REG4 gene. REG4 is associated with some diseases, including Ulcerative Colitis and Pseudomyxoma Peritonei.

REG4 Protein (6)

    REG4 Antibody (8)

      REG4 ELISA Kit & Match Antibody ELISA Pair Set (1)

      REG4 cDNA Clone (39)

      NM_032044.2
      NM_026328.1
      NM_001004096.1

      REG4 Lysate (6)

        REG4 Background

        Regenerating islet-derived protein 4, also known as REG-like protein, REG4, GISP and RELP, a member of the regenerating gene family belonging to the calcium (C-type) dependent lectin superfamily, has been found to be involved in malignancy in several different organs including the stomach, colorectum, pancreas and prostate. It is highly expressed in the gastrointestinal tract and markedly up-regulated in colon adenocarcinoma, pancreatic cancer, gastric adenocarcinoma, and inflammatory bowel disease. Expression of the Reg4 in different cell types has been associated with regeneration, cell growth and cell survival, cell adhesion and resistance to apoptosis. REG4 protein overexpression is associated with an unfavorable response to preoperative chemoradiotherapy and may be used as a predictive biomarker clinically. REG4 may play an important role in the development and progression of colorectal cancer, as well as in intestinal morphogenesis and epithelium restitution.

        REG4 References

        • Li FY, et al. (2010) RegIV expression showing specificity to gastrointestinal tract and its potential role in diagnosing digestive tract neuroendocrine tumor. J Zhejiang Univ Sci B. 11(4):258-66.
        • Rafa L, et al. (2010) REG4 acts as a mitogenic, motility and pro-invasive factor for colon cancer cells. Int J Oncol. 36(3): 689-98.
        • Hu G, et al. (2010) Purification of a bioactive recombinant human Reg IV expressed in Escherichia coli. Protein Expr Purif. 69(2): 186-90.

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