Receptor tyrosine kinases are a diverse group of transmembrane proteins that act as receptors for cytokines, growth factors, hormones and other signaling molecules. Receptor tyrosine kinase (RTK) is part of the larger family of protein tyrosine kinase. Receptor tyrosine kinases have been shown to play critical roles in a variety of cellular processes including growth, differentiation and angiogenesis, and in the development and progression of many types of cancer. It seems that Inhibition of receptor tyrosine kinases are effective measures in cancer treatment.
|• EGFRs (epidermal growth factor receptor family )||• PDGFRs (platelet-derived growth factor receptor family )|
|• NGFRs (nerve growth factor receptors family )||• FGFRs (fibroblast growth factor receptor family )|
|• IGF1Rs (insulin-like growth factor-1 receptor family )||• INSR (insulin receptor family )|
|• MCSFRs (macrophage colony stimulating factor receptor family )||• VEGFRs (vascular endothelial growth factor receptor family )|
|• HGFRs (hepatocyte growth factor receptor family )|
|• High purity: > 95%||• High Bio-activity||• Low endotoxin: <1.0 EU/μg|
|Here are Receptor Tyrosine Kinase （RTKs）protein catalytic activity assay results|
|Mouse EphB1 protein (50479-M20B) with Poly(Glu:Tyr) 4:1 substrate||Human EGFR / HER1 / ErbB1 protein (10001-H20B2)with Poly(Glu:Tyr) 4:1 substrate||Human IGF1R / CD221 protein(10164-H20B1) with Poly(Glu:Tyr) 4:1 substrate|
|• Various validated applications||• Multiple species||• High affinity & sensitivity|
| Human EGFR/ErbB1/HER1 in human placenta
|Human ErbB2 in SKBR3 cells (10004-R002)||Human Tie2 / CD202b / TEK in HUVEC cells
|• Expression validated||• Multiple tags||• Ready-to-use|
|GFP(GFPSpark®) Expression Validated||OFP(OFPSpark®) Expression Validated|
|Human HER2/ERBB2 transcript variant 1 GeneORF cDNA clone expression plasmid (HG10004-ACG)||Human HER2/ERBB2 transcript variant 1 GeneORF cDNA clone expression plasmid (HG10004-ACR)|
|• High sensitivity|
|Human EGFR / HER1 / ErbB1 ELISA Kit
|Human FGFR2 / CD332 ELISA Kit
|Human EphB6 / Eph Receptor B6 ELISA Kit
Receptor tyrosine kinase (RTKs) is one of the major signaling enzymes in cell signal transduction，which act as receptors for growth factors, neurotrophic factors and other extracellular signaling molecules,upon ligand binding, they undergo tyrosine phosphorylation at specific residues in the cytoplasmic tail，This leads to the binding of protein substrates and/or the establishment of docking sites for adaptor proteins involved in RTK-mediated signal transduction.promotes cell growth, survival, and proliferation， It is also closely related to the proliferation, differentiation, migration and apoptosis of tumor cells.
Receptor tyrosine kinase (RTKs) is one of the most successful drug targets in 518 known hormones，It is also a very important tumor drug target and plays an important role in cancer therapy. There are more than 20 kinds of small molecule kinase inhibitors approved by FDA for various cancer treatments, and there are a large number of kinase inhibitors in various stages of clinical trials.
1. Lemmon MA, Schlessinger J. Cell signaling by receptor tyrosine kinases [J].Cell,2010 ,141(7):1117-34.
2. Bennasroune A, et al. Tyrosine kinase receptors as attractive targets of cancer therapy[J]. Critical reviews in oncology/hematology, 2004, 50(1): 23-38.