RAC3 Antibodies, cDNA Clones Research Reagents

RAC3 (Rac Family Small GTPase 3), located on 17q25.3, is a Protein Coding gene. The gene produces a 21379 Da protein composed of 192 amino acids. The protein encoded by this gene is a GTPase which belongs to the Ras superfamily of small GTP-binding proteins. RAC3 shares 92% and 89% amino acid identity, respectively, with RAC1 and RAC2 but differs from RAC1 and RAC2 at its C-terminal end, a domain associated with subcellular localization and binding to specific cellular regulators. Rac3 plays an important role in neuronal development and tumor progression.

RAC3 Antibody (1)

    RAC3 cDNA Clone (16)

    NM_005052.2

    In expression vector

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    RAC3 Background

    RAC3 is a member of the p160 family of steroid receptor coactivators and it is highly expressed in several human cancers, contributing to enhanced cell proliferation and cellular transformation. RAC3 is an underexamined member of the Rho GTPase gene family that is expressed in the developing brain and linked to key cellular functions. The Rac3 polypeptide is highly similar to Rac1, and orthologues of the gene for Rac3 have been found only in vertebrates, indicating the late appearance of this gene during evolution. Rac3 plays an important role in neuronal development and tumor progression, with specificities that distinguish the functions of Rac3 from the established functions of Rac1. De novo missense variants in the homolog RAC1 were recently associated with developmental disorders. RAC3 is a key regulator of adipogenesis since its downregulation generates the cellular arrest and autophagic responses that are required steps for this process.

    RAC3 References

    • Lira MC, et al. (2018) Role of rac3 coactivator in the adipocyte differentiation. Cell Death Discov 4 20.
    • de Curtis I (2019) The rac3 gtpase in neuronal development, neurodevelopmental disorders, and cancer. Cells 8 (9): 1063.
    • Costain G, et al. (2019) De novo missense variants in rac3 cause a novel neurodevelopmental syndrome. Genet Med 21 (4): 1021-1026.

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