PTP alpha/PTPRA Proteins, Antibodies, cDNA Clones Research Reagents

PTPRA (Protein Tyrosine Phosphatase Receptor Type A) is a protein coding gene located on human chromosome 20p13. PTPRA is also known as LRP, HLPR, PTPA, HEPTP, HPTPA, RPTPA, PTPRL2, HPTPalpha and R-PTP-alpha. The human PTPRA gene encodes a 90719 Da protein containing 802 amino acids. The PTPRA protein is ubiquitously expressed in brain, thyroid and other tissues. Among its related pathways are RET signaling and Signaling by GPCR. PTPRA is related to phosphatase activity and transmembrane receptor protein tyrosine phosphatase activity. PTPRE is an important paralog of PTPRA gene. PTPRA is associated with some diseases, such as Common Peroneal Nerve Lesion.

PTP alpha/PTPRA Protein (1)

    PTP alpha/PTPRA Antibody (1)

      PTP alpha/PTPRA cDNA Clone (13)

      NM_002836.3

      PTP alpha/PTPRA Lysate (1)

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        PTP alpha/PTPRA Background

        PTPRA is reported to be involved in cancer development and progression through activating the Src family kinase (SFK) signaling pathways. The higher PTPRA level was associated with worse prognosis of SCC patients and PTPRA could promote the cell cycle progression through stimulating the c-Src signaling pathways. The PTPRA gene, which encodes the protein RPTP-alpha, is critical to neurodevelopment. Previous linkage studies, genome-wide association studies, controlled expression analyses and animal models support an association with both schizophrenia and autism spectrum disorders, both of which share a substantial portion of genetic risks.

        PTP alpha/PTPRA References

        • Kaplan R, et al. (1990) Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain. Proc Natl Acad Sci U S A. 87 (18): 7000-4.
        • Hertog JD, et al. (1996) Tight association of GRB2 with receptor protein-tyrosine phosphatase alpha is mediated by the SH2 and C-terminal SH3 domains. EMBO J. 15 (12): 3016-27.
        • Ye H, et al. (2011) Receptor-like protein-tyrosine phosphatase a enhances cell surface expression of neural adhesion molecule NB-3. J Biol Chem. 286 (29): 26071-80.

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