Psoriasin/S100A7 Proteins, Antibodies, cDNA Clones Research Reagents

S100A7 (S100 Calcium Binding Protein A7) is a protein coding gene located on human chromosome 1q21.3. S100A7 is also known as PSOR1 and S100A7c. The human S100A7 gene encodes a 11471 Da protein containing 101 amino acids. The S100A7 protein is restrictedly expressed toward skin. Among its related pathways are Validated targets of C-MYC transcriptional repression and Innate Immune System. S100A7 is related to calcium ion binding and RAGE receptor binding. S100A7A is an important paralog of S100A7 gene. S100A7 is associated with some diseases, including Bladder Squamous Cell Carcinoma and Anal Fistula.

Psoriasin/S100A7 Protein (1)

    Psoriasin/S100A7 Antibody (8)

      Psoriasin/S100A7 cDNA Clone (15)

      Psoriasin/S100A7 qPCR Primer (1)

      Psoriasin/S100A7 Background

      Protein S100-A7, also known as S100 calcium-binding protein A7, Psoriasin, S100A7, and PSOR1, is a secreted protein which belongs to theS-100 family. S100A7 was first isolated from skin involved by psoriasis, which can be induced in cultured squamous epithelial cells. S100A7 is expressed by both normal cultured and malignant keratinocytes and malignant breast epithelial cells within ductal carcinoma in situ, suggesting an association with abnormal pathways of differentiation. S100A7 plays a role in the pathogenesis of inflammatory skin disease, as a chemotactic factor for hematopoietic cells. It also plays a role in early stages of breast tumor progression in association with the development of the invasive phenotype.

      Psoriasin/S100A7 References

      • Miyasaki, KT. et al., 1993, J. Dent. Res. 72: 517-23.
      • Watson, PH. et al., 1998, Int J Biochem Cell Biol  30 (5):567-71.
      • Emberley, ED. et al., 2004, Breast Cancer Res  6 (4): 153-9.
      • Ohuchida, K. et al., 2006, Clin Cancer Res  12 (18):5417-22.
      • Kouno, T. et al., 2008, J Pept Sci. 14 (10):1129-38.
      • León, R. et al., 2009, Biochemistry. 48 (44): 10591-600.

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