PRSS3 Proteins, Antibodies, cDNA Clones Research Reagents

PRSS3 (Serine Protease 3) is a protein coding gene located on human chromosome 9p13.3. PRSS3 is also known as T9, MTG, TRY3, TRY4, and PRSS4. The human PRSS3 gene encodes a 32529 Da protein containing 304 amino acids. The PRSS3 protein is restrictedly expressed toward pancreas. Among its related pathways are Collagen chain trimerization and Defensins. PRSS3 is related to calcium ion binding and serine-type peptidase activity. PRSS2 is an important paralog of PRSS3 gene. PRSS3 is associated with some diseases, including Thyroiditis and Rickettsialpox.

PRSS3 Protein (1)

    PRSS3 Antibody (3)

      PRSS3 cDNA Clone (40)


      In cloning vector


      PRSS3 Lysate (1)

        PRSS3 Background

        Trypsin-3, also known as Trypsin III, brain trypsinogen, Serine protease 3 and PRSS3, is a secreted protein that belongs to the peptidase S1 family. Trypsin-3 / PRSS3 is expressed is in pancreas and brain. It contains one peptidase S1 domain. Trypsin-3 / PRSS3 can degrade intrapancreatic trypsin inhibitors that protect against CP. Genetic variants that cause higher mesotrypsin activity might increase the risk for chronic pancreatitis (CP). A sustained imbalance of pancreatic proteases and their inhibitors seems to be important for the development of CP. The trypsin inhibitor-degrading activity qualified PRSS3 as a candidate for a novel CP susceptibility gene. Trypsin-3 / PRSS3 has been implicated as a putative tumor suppressor gene due to its loss of expression, which is correlated with promoter hypermethylation, in esophageal squamous cell carcinoma and gastric adenocarcinoma.

        PRSS3 References

        • Venter JC. et al., 2001, Science 291:1304-51.
        • Marsit,CJ. et al., 2005, Mol Carcinog 44 (2):146-50.
        • Rowen, L. et al., 2005, Mol Biol Evol. 22 (8):1712-20.
        • Rosendahl, J. et al., 2010, Pancreatology. 10 (2-3):243-9

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