PRSS3 Proteins, Antibodies, cDNA Clones Research Reagents

All PRSS3 reagents are produced in house and quality controlled, including 3 PRSS3 Antibody, 40 PRSS3 Gene, 1 PRSS3 Lysate, 1 PRSS3 Protein, 2 PRSS3 qPCR. All PRSS3 reagents are ready to use.

PRSS3 Protein (1)

    PRSS3 Antibody (3)

      PRSS3 cDNA Clone (40)


      In cloning vector


      PRSS3 Lysate (1)

        PRSS3 Background

        Trypsin-3, also known as Trypsin III, brain trypsinogen, Serine protease 3 and PRSS3, is a secreted protein which belongs to thepeptidase S1 family. Trypsin-3 / PRSS3 is expressed is in pancreas and brain. It contains onepeptidase S1 domain. Trypsin-3 / PRSS3 can degrade intrapancreatic trypsin inhibitors that protect against CP. Genetic variants that cause higher mesotrypsin activity might increase the risk for chronic pancreatitis (CP). A sustained imbalance of pancreatic proteases and their inhibitors seems to be important for the development of CP. The trypsin inhibitor-degrading activity qualified PRSS3 as a candidate for a novel CP susceptibility gene. Trypsin-3 / PRSS3 has been implicated as a putative tumor suppressor gene due to its loss of expression, which is correlated with promoter hypermethylation, in esophageal squamous cell carcinoma and gastric adenocarcinoma.

        PRSS3 References

        • Venter JC. et al., 2001, Science 291:1304-51.
        • Marsit,CJ. et al., 2005, Mol Carcinog 44 (2):146-50.
        • Rowen, L. et al., 2005, Mol Biol Evol. 22 (8):1712-20.
        • Rosendahl, J. et al., 2010, Pancreatology. 10 (2-3):243-9

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