Prolactin Proteins, Antibodies, cDNA Clones Research Reagents

PRL (Prolactin) is a protein coding gene located on human chromosome 6p22.3. PRL is also known as GHA1. The human PRL gene encodes a 25876 Da protein containing 227 amino acids. The PRL protein is biasedly expressed in placenta and endometrium. Among its related pathways are Prolactin Signaling Pathway and PEDF Induced Signaling. PRL is related to hormone activity and prolactin receptor binding. CSH2 is an important paralog of PRL gene. PRL is associated with some diseases, including Impotence and Pituitary Gland Disease.

Prolactin Protein (2)

    Prolactin Antibody (2)

      Prolactin cDNA Clone (26)


      Prolactin Lysate (2)

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        Prolactin Background

        Prolactin (PRL) is a hormone with multiple actions in the central nervous system (CNS) spanning from physiology to pathology. PRL exerts different actions through its receptors that can be found in both neurons and glial cells (astrocytes, microglia and oligodendrocytes) of the brain. It is generally believed that in vertebrates, prolactin (PRL) is predominantly synthesized and released by pituitary lactotrophs and plays important roles in many physiological processes via activation of PRL receptor (PRLR), including water and electrolyte balance, reproduction, growth and development, metabolism, immuno-modulation, and behavior.

        Prolactin References

        • Jara LJ, et al. (2011) Prolactin and autoimmunity. Clin Rev Allergy Immunol. 40(1): 50-9.
        • Urban A, et al. (2007) Prolactin as a factor for increased platelet aggregation. Neuro Endocrinol Lett. 28(4): 518-23.
        • Charoenphandhu N, et al. (2007) Prolactin is an important regulator of intestinal calcium transport. Can J Physiol Pharmacol. 85(6): 569-81.
        • Tworoger SS, et al. (2006) Prolactin and breast cancer risk. Cancer Lett. 243(2): 160-9.
        • Ben-Jonathan N, et al. (2006) Focus on prolactin as a metabolic hormone. Trends Endocrinol Metab. 17(3): 110-6.

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