PRMT3 Proteins, cDNA Clones Research Reagents

All PRMT3 reagents are produced in house and quality controlled, including 30 PRMT3 Gene, 1 PRMT3 Protein, 1 PRMT3 qPCR. All PRMT3 reagents are ready to use.

PRMT3 Protein (1)

    PRMT3 cDNA Clone (30)

    PRMT3 qPCR Primer (1)

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    PRMT3 Background

    Protein arginine methyltransferase 3, also known as PRMT3, is one of four type I protein arginine methyltransferases (PRMT) that in humans is encoded by the PRMT3gene. Methylation of arginine residues is a widespread post-translational modification of proteins catalyzed by a small family of PRMTs. The modification appears to regulate protein functions and interactions that affect gene regulation, signalling and subcellular localization of proteins and nucleic acids. In human cells, the PRMT family consists of eight canonical members. PRMTs have been classified into two groups based on the end product. Certain PRMTs display different subcellular localization in different cell types, implicating cell- and tissue-specific mechanisms for regulating PRMT functions. PRMT3 is unique in that its N-terminus harbours a C2H2 zinc-finger domain that is proposed to confer substrate specificity. In addition, PRMT3 is the only type I enzyme that is restricted to the cytoplasm. A large proportion of this cystosolic PRMT3 is found associated with ribosomes. It is tethered to the ribosomes through its interaction with rpS2, which is also its substrate.

    PRMT3 References

    • Swiercz, R. et al., 2005, Biochem J. 386 (Pt 1): 85-91.
    • Iwasaki, H., 2008, Biochem Biophys Res Commun  372 (2): 314-9.
    • Lei, NZ. et al., 2009, Nucleic acids Res 37 (3): 832-48.
    • Fan, Q. et al., 2009, Biochem J. 421 (1): 107-18.
    • Herrmann, FJ. et al., 2009, Cell Sci. 122 (Pt 5): 667-77.
    • Kölbel, K. J Biol Chem 2009, 284 (13): 8274-82.

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