PPARA cDNA Clones Research Reagents

PPARA (Peroxisome Proliferator Activated Receptor Alpha) is a protein coding gene located on human chromosome 22q13.31. PPARA is also known as PPAR, NR1C1, hPPAR and PPARalpha. The human PPARA gene encodes a 52225 Da protein containing 468 amino acids. The PPARA protein is ubiquitously expressed in kidney, heart and other tissues. Among its related pathways are Organelle biogenesis and maintenance and Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha). PPARA is related to DNA-binding transcription factor activity. PPARD is an important paralog of PPARA gene. PPARA is associated with some diseases, including Fatty Liver Disease and Lipid Metabolism Disorder.

PPARA cDNA Clone (15)

PPARA qPCR Primer (1)

PPARA Background

Peroxisome proliferators include hypolipidemic drugs, herbicides, leukotriene antagonists, and plasticizers; this term arises because they induce an increase in the size and number of peroxisomes. Peroxisomes are subcellular organelles found in plants and animals that contain enzymes for respiration and for cholesterol and lipid metabolism. The action of peroxisome proliferators is thought to be mediated via specific receptors, called PPARs, which belong to the steroid hormone receptor superfamily. PPARs affect the expression of target genes involved in cell proliferation, cell differentiation and in immune and inflammation responses. Three closely related subtypes (alpha, beta/delta, and gamma) have been identified. This gene encodes the subtype PPAR-alpha, which is a nuclear transcription factor. Multiple alternatively spliced transcript variants have been described for this gene, although the full-length nature of only two has been determined.

PPARA References

  • Janssen AWF, Betzel B, Stoopen G, et al. The impact of PPARα activation on whole genome gene expression in human precision cut liver slices. BMC Genomics. 2015;16:760.

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