PMP2 Proteins, Antibodies, cDNA Clones Research Reagents

PMP2 (Peripheral Myelin Protein 2) is a protein coding gene located on human chromosome 8q21.13. PMP2 is also known as P2, MP2, CMT1G, FABP8, and M-FABP. The human PMP2 gene encodes a 14909 Da protein containing 132 amino acids. The PMP2 protein is restrictedly expressed toward brain. PMP2 is related to transporter activity and cholesterol binding. FABP9 is an important paralog of PMP2 gene. PMP2 is associated with some diseases, including Charcot-Marie-Tooth Disease, Demyelinating, Type 1G and Neuritis.

PMP2 Protein (1)

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      PMP2 cDNA Clone (15)

      PMP2 qPCR Primer (1)

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      PMP2 Background

      Myelin P2 protein, also known as PMP2, is a cytosolic protein found primarily in peripheral nerves. It Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. PMP2 is a small, basic, and cytoplasmic lipid binding protein of peripheral myelin. It is similar in amino acid sequence and tertiary structure to fatty acid binding proteins found in the liver, adipocytes, and intestine, its expression is limited to the nervous system. PMP2 is detected only in myelin-producing cells of the central and peripheral nervous systems, the oligodendrocytes and Schwann cells, respectively. PMP2 may play a role in lipid transport protein in Schwann cells. It forms a beta-barrel structure that accommodates hydrophobic ligands in its interior.

      PMP2 References

      • Hayasaka, K. et al., 1993, Genomics. 18 (2): 244-8.
      • Polverini, E. et al., 2006, J Struct Biol. 153 (3): 253-63.
      • Gould,R.M. et al., 2008, Neuron Glia Biol. 4 (2):137-52.

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