PML Antibodies, cDNA Clones Research Reagents

PML (PML Nuclear Body Scaffold) is a protein coding gene located on human chromosome 15q24.1. PML is also known as MYL, RNF71, PP8675 and TRIM19. The human PML gene encodes a 97551 Da protein containing 882 amino acids. The PML protein is ubiquitously expressed in fat, spleen and other tissues. Among its related pathways are Regulation of TP53 Activity through Acetylation and Transcriptional misregulation in cancer. PML is related to protein homodimerization activity and transcription coactivator activity. TRIM55 is an important paralog of PML gene. PML is associated with some diseases, including Acute Promyelocytic Leukemia and Rabies.

PML Antibody (2)

    PML cDNA Clone (1)


    In expression vector

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    PML Background

    Promyelocytic leukemia protein (PML) nuclear bodies (NBs), which are sub-nuclear protein structures, are involved in a variety of important cellular functions.PML is a tumour suppressor and regulator of cell differentiation. PML-NBs are assembled by PML isoforms, and contact between small ubiquitin-like modifiers (SUMOs) with the SUMO interaction motif (SIM) are critically involved in this process. PML isoforms contain a common N-terminal region and a variable C-terminus. The PML (promyelocytic leukemia) protein is a member of the TRIM family, a large group of proteins that show high diversity in functions but possess a common tripartite motif giving the family its name. Promyelocytic leukemia (PML), which is a tumor suppressor protein that nevertheless plays an important role in the maintenance of leukemia initiating cells, is known to be biochemically modified by As(3+).

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