Pleiotrophin/PTN Proteins, cDNA Clones Research Reagents

PTN (Pleiotrophin) is a protein coding gene located on human chromosome 7q33. PTN is also known as HARP, HBBM, HBNF, HBGF8, NEGF1, OSF-1, HB-GAM, HBGF-8 and HBNF-1. The human PTN gene encodes a 18942 Da protein containing 168 amino acids. The PTN protein is broadly expressed in brain, prostate and other tissues. Among its related pathways are NF-KappaB Family Pathway and Activation of cAMP-Dependent PKA. PTN is related to growth factor activity and protein phosphatase inhibitor activity. MDK is an important paralog of PTN gene. PTN is associated with some diseases, including Peyronie's Disease and Nasal Cavity Olfactory Neuroblastoma.

Pleiotrophin/PTN Protein (3)

    Pleiotrophin/PTN cDNA Clone (39)


    Pleiotrophin/PTN Lysate (3)

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      Pleiotrophin/PTN Background

      HB-GAM belongs to the pleiotrophin family. During embryonic and early postnatal development, HB-GAM is expressed in the central and peripheral nervous system and also in several non-neural tissues, notably lung, kidney, gut and bone. While in the adult central nervous system, it is expressed in an activity-dependent manner in the hippocampus where it can suppress long term potentiation induction. HB-GAM has a low expression in other areas of the adult brain, but it can be induced by ischemic insults, or targeted neuronal damage in the entorhinal cortex or in the substantia nigra pars compacta. It is structurally related to midkine and retinoic acid induced heparin-binding protein and has a high affinity for heparin. HB-GAM binds anaplastic lymphoma kinase (ALK) which induces MAPK pathway activation, an important step in the anti-apoptotic signaling of PTN and regulation of cell proliferation. It also functions as a secreted growth factor and induces neurite outgrowth and which is mitogenic for fibroblasts, epithelial, and endothelial cells.

      Pleiotrophin/PTN References

      • Vanderwinden JM, et al. (1992) Cellular distribution of the new growth factor pleiotrophin (HB-GAM) mRNA in developing and adult rat tissues. Anat Embryol. 186(4):387-406.
      • Lauri SE, et al. (1996) Activity-induced enhancement of HB-GAM expression in rat hippocampal slices. Neuroreport. 7(10):1670-4.
      • Pavlov I, et al. (2002) Role of heparin-binding growth-associated molecule (HB-GAM) in hippocampal LTP and spatial learning revealed by studies on overexpressing and knockout mice. Mol Cell Neurosci. 20(2):330-42.

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