PIAS3 Antibodies, cDNA Clones Research Reagents

PIAS3 (Protein Inhibitor Of Activated STAT 3, also known as ZMIZ5), located on 1q21.1, is a Protein Coding gene. This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The gene produces a 68017 Da protein composed of 628 amino acids. PIAS3 is an endogenous suppressor of signal transducer and activator of transcription 3 (STAT3) signaling and cell growth and demonstrates limited expression in the majority of human squamous cell carcinomas of the lung.

PIAS3 Antibody (1)

    PIAS3 cDNA Clone (2)

    BC001154

    In expression vector

    In lentiviral vector

    PIAS3 qPCR Primer (1)

    PIAS3 Background

    Protein inhibitor of activated STAT3 (PIAS3) is a member of the protein inhibitor of activated STAT (PIAS) family. PIAS3 is an endogenous suppressor of signal transducer and activator of transcription 3 (STAT3) signaling and cell growth and demonstrates limited expression in the majority of human squamous cell carcinomas of the lung. By directly interacting with phosphorylated STAT3, PIAS3 can block the downstream transcriptional activity of STAT3, which is hyper-activated in various cancers. PIAS3 is the only member of the PIAS family that is indispensable for ATR activation. In response to different types of DNA damage and replication stress, PIAS3 plays multiple roles in ATR activation. STAT3 is implicated in guiding the specification of rod and cone photoreceptors through post-translational modification of key retinal transcription factors.

    PIAS3 References

    • Wu CS, et al. (2016) The sumo (small ubiquitin-like modifier) ligase pias3 primes atr for checkpoint activation. J Biol Chem 291 (1): 279-290.
    • He T, et al. (2018) Post-transcriptional regulation of pias3 expression by mir-18a in malignant mesothelioma. Mol Oncol 12 (12): 2124-2135.
    • Dabir S, et al. (2014) Pias3 activates the intrinsic apoptotic pathway in non-small cell lung cancer cells independent of p53 status. Int J Cancer 134 (5): 1045-1054.
    • Campla CK, et al. (2017) Pias3 is necessary for dorso-ventral patterning and visual response of retinal cones but is not required for rod photoreceptor differentiation. Biol Open 6 (6): 881-890.

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