PIAS1 Antibodies, cDNA Clones Research Reagents

PIAS1 (Protein Inhibitor Of Activated STAT 1, also known as GBP; ZMIZ3; DDXBP1; GU/RH-II), located on 15q23, is a Protein Coding gene. This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. The gene produces a 71836 Da protein composed of 651 amino acids. Like other members of the PIAS family, the predicted 651-amino acid human PIAS1 protein contains a putative zinc-binding motif and a highly acidic region. Diseases such as Borderline Glaucoma and Testicular Germ Cell Cancer are associated with PIAS1.

PIAS1 Antibody (2)

    PIAS1 cDNA Clone (30)

    PIAS1 qPCR Primer (1)

    PIAS1 Background

    Protein inhibitor of activated STAT1 (signal transducer and activator of transcription 1) (PIAS1) was identified as a cellular protein binding to N. PIAS1 is known to bind to p65 (RelA) in the nucleus and blocks its DNA binding, thus functions as a repressor of NF-κB. Binding of N to PIAS1 released p65 for NF-κB activation. The N-terminal half of PIAS1 was mapped as the N-binding domain, and this region overlapped its p65-binding domain. For N, the region between 37 and 72 aa was identified as the binding domain to PIAS1, and this domain alone was able to activate NF-κB. PIAS1 is one of the few known SUMO E3 ligases. PIAS1 has been implicated in several biological processes including repression of innate immunity and DNA repair. PIAS1 is a key regulator of STAT1 signaling and may be implicated in carcinogenesis.

    PIAS1 References

    • Ke H, et al. (2019) Interaction of pias1 with prrs virus nucleocapsid protein mediates nf-κb activation and triggers proinflammatory mediators during viral infection. Sci Rep 9 (1): 11042.
    • Erb HHH, et al. (2019) Pias1 is not suitable as a urothelial carcinoma biomarker protein and pharmacological target. PLoS One 14 (10): e0224085.
    • Constanzo JD, et al. (2016) Pias1 is essential for erythroid and vascular development in the mouse embryo. Dev Biol 415 (1): 98-110.

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