PGLYRP1 Proteins, cDNA Clones Research Reagents

PGLYRP1 (Peptidoglycan Recognition Protein 1) is a protein coding gene located on human chromosome 19q13.32. PGLYRP1 is also known as PGRP, TAG7, PGRPS, PGLYRP, PGRP-S and TNFSF3L. The human PGLYRP1 gene encodes a 21731 Da protein containing 196 amino acids. The PGLYRP1 protein is restrictedly expressed toward bone marrow. Among its related pathways are Innate Immune System and Defensins. PGLYRP1 is related to peptidoglycan binding and N-acetylmuramoyl-L-alanine amidase activity. PGLYRP3 is an important paralog of PGLYRP1 gene. PGLYRP1 is associated with some diseases, including Spherocytosis, Type 2 and Mite Infestation.

PGLYRP1 Protein (1)

    PGLYRP1 cDNA Clone (26)

    NM_005091.1
    NM_009402.2

    PGLYRP1 Lysate (1)

      PGLYRP1 Background

      Peptidoglycan recognition protein 1, also known as Peptidoglycan recognition protein short, PGRP-S, PGLYRP1, PGLYRP, PGRP and TNFSF3L, is a secreted protein that belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. PGLYRP1 / PGLYRP is highly expressed in bone marrow. It is weakly expressed in kidney, liver, small intestine, spleen, thymus, peripheral leukocyte, lung, fetal spleen and neutrophils. PGLYRP1 / PGLYRP is a pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. It has bactericidal activity towards Gram-positive bacteria. PGLYRP1 / PGLYRP may kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. It binds also to Gram-negative bacteria, and has bacteriostatic activity towards Gram-negative bacteria. Peptidoglycan recognition proteins (PGRPs or PGLYRPs) are innate immunity proteins that are conserved from insects to mammals, recognize bacterial peptidoglycan, and function in antibacterial immunity and inflammation. Mammals have four PGRPs: PGLYRP1, PGLYRP2, PGLYRP3, and PGLYRP4. They are secreted proteins expressed in polymorphonuclear leukocytes (PGLYRP1), liver (PGLYRP2), or on body surfaces, mucous membranes, and in secretions (saliva, sweat) (PGLYRP3 and PGLYRP4). All PGRPs recognize bacterial peptidoglycan. The PGRPs likely play a role both in antibacterial defenses and several inflammatory diseases. They modulate local inflammatory responses in tissues (such as arthritic joints) and there is evidence for association of PGRPs with inflammatory diseases, such as psoriasis.

      PGLYRP1 References

      • Kang D., et al.,(1998), A peptidoglycan recognition protein in innate immunity conserved from insects to humans. Proc. Natl. Acad. Sci. U.S.A. 95:10078-10082.
      • Liu C., et al., (2001), Peptidoglycan recognition proteins: a novel family of four human innate immunity pattern recognition molecules.J. Biol. Chem. 276:34686-34694.
      • Clark H.F., et al.,(2003), The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.Genome Res. 13:2265-2270.

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