PGA4 Proteins, Antibodies, cDNA Clones Research Reagents

PGA4 (Pepsinogen A4) is a protein coding gene located on human chromosome 11q12.2. The human PGA4 gene encodes a 41977 Da protein containing 388 amino acids. The PGA4 protein is restrictedly expressed toward stomach. Among its related pathways are Collagen chain trimerization and Metabolism of proteins. PGA4 is related to aspartic-type endopeptidase activity. PGA5 is an important paralog of PGA4 gene. PGA4 is associated with some diseases, including Atrophic Gastritis and Gastritis.

PGA4 Protein (2)

    PGA4 Antibody (6)

      PGA4 cDNA Clone (13)


      PGA4 qPCR Primer (1)

      PGA4 Lysate (2)

        PGA4 Background

        PGA4 (Pepsinogen 4, group I), or Pepsinogen A, is a member of the peptidase A1 family. Pepsin is expressed as a pro-form zymogen, pepsinogen, whose primary structure has an additional 44 amino acids. Pepsin is stored as pepsinogen so it will only be released when needed, and does not digest the body's own proteins in the stomach's lining. Five types of zymogens of pepsins, gastric digestive proteinases, are known: pepsinogens A, B, and F, progastricsin, and prochymosin. There are two major groups of pepsinogen, namely pepsinogen A (PGA) and pepsinogen C (PGC) (or progastricsin), and each frequently has isozymogens. The PGA3, PGA4 and PGA5 genes encode identical human pepsinogen A enzymes.

        PGA4 References

        • Kageyama T. (2002) Pepsinogens, progastricsins, and prochymosins: structure, function, evolution, and development. Cell Mol Life Sci. 59(2): 288-306.
        • Takahashi K. (1992) Gene structures of pepsinogens A and C. Scand J Clin Lab Invest Suppl. 210: 97-110.

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