PEDF Proteins, Antibodies, cDNA Clones Research Reagents

SERPINF1 (Serpin Family F Member 1) is a protein coding gene located on human chromosome 17p13.3. SERPINF1 is also known as OI6, OI12, PEDF, EPC-1, and PIG35. The human SERPINF1 gene encodes a 46312 Da protein containing 418 amino acids. The SERPINF1 protein is broadly expressed in liver, gall bladder and other tissues. Among its related pathways are Apoptotic Pathways in Synovial Fibroblasts and Wnt signaling pathway. SERPINF1 is related to serine-type endopeptidase inhibitor activity. SERPINF2 is an important paralog of SERPINF1 gene. SERPINF1 is associated with some diseases, including Osteogenesis Imperfecta, Type Vi and Osteogenesis Imperfecta, Type Iv.

PEDF Protein (3)

    PEDF Antibody (10)

      PEDF cDNA Clone (39)


      PEDF Lysate (3)

        PEDF Background

        Pigment epithelium-derived factor, also known as PEDF, Serpin F1, and SERPINF1, is a multiple functional protein that has both anti-angiogenic activity and neurotrophic activity at the same time. PEDF is a secreted glycoprotein that belongs to the noninhibitory serpin. It has an alpha/beta core serine-protease inhibitor domain, three major beta-sheets, and ten alpha-helices. PEDF does not inhibit either serine or cysteine proteinases. PEDF exerts diverse physiological activities including anti-angiogenesis, anti-vasopermeability, anti-tumor, and neurotrophic activities. PEDF acts via multiple high affinity ligands and cell receptors. It has been described as a natural angiogenesis inhibitor with neurotrophic and immune-modulation properties. PEDF induces macrophages apoptosis and necrosis through the activation of peroxisome proliferator-activated receptor-gamma by which PEDF could modulate inflammatory reactions in septic shock. It balances angiogenesis in the eye and blocks tumor progression.

        PEDF References

        • Ren, JG. et al., 2005, Med Hypotheses. 64 (1): 74-8.
        • Filleur, S. et al., 2009. J Cell Biochem. 106 (5): 769-75.
        • Kawaguchi, T. et al., 2010, Curr Mol Med. 10 (3): 302-11.
        • Yamagishi, SI. et al., 2010, Curr Mol Med. 10 (3): 284-91.
        • Nakamura, T. et al., 2010, Curr Mol Med. 10 (3): 312-6.

        Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.